Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

GO:0008897

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Holo-[acyl-carrier-protein] synthase activity
Full defintion Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.
Subterm of

Relationships

The relationship of GO:0008897 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0008897, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

  • Drag and drop nodes to manually position (i.e. fix) them
  • Double click on a node to unfix the node
  • Press Alt and double click to visit the page containing further details of a GO term
  • Right clicking on a node will reveal a context menu

Controls

Force layout

Every force layout is different—we have picked a set of parameters which suits most GO ancestor tree chart well. If you mess something up—don't worry: hitting the "reset view" button above will reset the chart to its default layout.

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
EC2.7.8.7
PMID
A new enzyme superfamily - the phosphopantetheinyl transferases.Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT
Chem Biol. 1996 Nov; 3 (11): 923–36.PMID: 8939709

All polyketide synthases, fatty acid synthases, and non-ribosomal peptide synthetases require posttranslational modification of their constituent acyl carrier protein domain(s) to become catalytically active. The inactive apoproteins are converted to their active holo-forms by posttranslational transfer of the 4'-phosphopantetheinyl (P-pant) moiety of coenzyme A to the sidechain hydroxyl of a conserved serine residue in each acyl carrier protein domain. The first P-pant transferase to be cloned and characterized was the recently reported Escherichia coli enzyme ACPS, responsible for apo to holo conversion of fatty acid synthase. Surprisingly, initial searches of sequence databases did not reveal any proteins with significant peptide sequence similarity with ACPS.

Associated Lotus transcripts 18

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0063229.1
– PREDICTED: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase-like [Glycine max] gi|356555754|ref|XP_003546195.1|
GO terms
2
Lj0g3v0125189.2
– 4'-phosphopantetheinyl transferase [Medicago truncatula] gi|357520283|ref|XP_003630430.1|
GO terms
2
Lj0g3v0338739.2
– 4'-phosphopantetheinyl transferase [Medicago truncatula] gi|357520285|ref|XP_003630431.1|
GO terms
2
Lj0g3v0338739.3
– PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1|
GO terms
2
Lj0g3v0338739.4
– PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1|
GO terms
2
Lj4g3v0686460.1
– PREDICTED: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase-like [Glycine max] gi|356555754|ref|XP_003546195.1|
GO terms
2
Lj6g3v1692450.1
– PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1|
GO terms
2
Lj6g3v1692530.2
– PREDICTED: 4'-phosphopantetheinyl transferase-like [Glycine max] gi|356546091|ref|XP_003541465.1|
GO terms
2
LotjaGi5g1v0096600.1
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi5g1v0096600
GO terms
2
LotjaGi5g1v0096600.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi5g1v0096600
GO terms
2
LotjaGi6g1v0021000.1
– 4'-phosphopantetheinyl transferase family protein; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|B2RYJ4|ADPPT_RAT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A0B2RKT0|A0A0B2RKT0_GLYSO L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0021000
GO terms
2
LotjaGi6g1v0267400_LC.1
– Holo-[acyl]-carrier-protein] synthase; TAIR: AT3G11470.2 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A072VJ05|A0A072VJ05_MEDTR 4'-phosphopantetheinyl transferase family protein; Found in the gene: LotjaGi6g1v0267400_LC
GO terms
2
LotjaGi6g1v0267400_LC.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.4 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P37695|HETI_NOSS1 4'-phosphopantetheinyl transferase HetI; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0267400_LC
GO terms
2
LotjaGi6g1v0267400_LC.3
– Holo-[acyl]-carrier-protein] synthase; TAIR: AT3G11470.2 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A072VJ05|A0A072VJ05_MEDTR 4'-phosphopantetheinyl transferase family protein; Found in the gene: LotjaGi6g1v0267400_LC
GO terms
2
LotjaGi6g1v0275500_LC.1
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0275500_LC
GO terms
2
LotjaGi6g1v0275500_LC.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39144|LP14_BACIU 4'-phosphopantetheinyl transferase; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0275500_LC
GO terms
2
LotjaGi6g1v0276000_LC.1
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39135|SFP_BACSU 4'-phosphopantetheinyl transferase sfp; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0276000_LC
GO terms
2
LotjaGi6g1v0276000_LC.2
– 4'-phosphopantetheinyl transferase; TAIR: AT3G11470.1 4'-phosphopantetheinyl transferase superfamily; Swiss-Prot: sp|P39135|SFP_BACSU 4'-phosphopantetheinyl transferase sfp; TrEMBL-Plants: tr|A0A151RRT2|A0A151RRT2_CAJCA 4'-phosphopantetheinyl transferase; Found in the gene: LotjaGi6g1v0276000_LC
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0008897
Molecular function Holo-[acyl-carrier-protein] synthase activity 1 5.56