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GO:0016274

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Protein-arginine N-methyltransferase activity
Full defintion Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
Subterm of

Relationships

The relationship of GO:0016274 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCmah
PMID
Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function.Teyssier C, Chen D, Stallcup MR
J Biol Chem. 2002 Nov 29; 277 (48): 46066–72.PMID: 12351636

The p160 coactivator complex plays a critical role in transcriptional activation by nuclear receptors and possibly other classes of DNA-binding transcriptional activators. The complex contains at least one of three p160 coactivators (SRC-1, GRIP1/TIF2, or pCIP/RAC3/ACTR/AIB1/TRAM1), a histone acetyltransferase such as CBP or p300, and the histone methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1). Methylation of histone H3 and possibly other proteins in the transcription initiation complex by CARM1 occurs along with acetylation of histones and other proteins by CBP and p300 to help remodel chromatin structure and recruit RNA polymerase II. Here we show that other domains of CARM1 are required for the coactivator function of CARM1 in addition to the methyltransferase activity. The methyltransferase GRIP1, binding, and homo-oligomerization activities all reside in the central region of CARM1, which is highly conserved among the entire protein arginine methyltransferase family. In addition to this conserved domain, the unique N- and C-terminal regions of CARM1 were also required for enhancement of transcriptional activation by nuclear receptors. While the N-terminal region has no known activity at present, the C-terminal part of CARM1 contains an autonomous activation domain, suggesting that it interacts with other proteins that help to mediate CARM1 coactivator function.

Associated Lotus transcripts 28

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0087819.1
– PREDICTED: probable protein arginine N-methyltransferase 3-like [Cicer arietinum] gi|502124794|ref|XP_004498675.1|
GO terms
2
Lj0g3v0266829.1
– PREDICTED: probable protein arginine N-methyltransferase 4.2-like [Glycine max] gi|356508346|ref|XP_003522918.1|
GO terms
2
Lj1g3v1965080.1
– PREDICTED: protein arginine N-methyltransferase 1.5-like [Glycine max] gi|356515519|ref|XP_003526447.1|
GO terms
2
Lj2g3v0910600.1
– PREDICTED: probable protein arginine N-methyltransferase 1-like [Glycine max] gi|356520854|ref|XP_003529075.1|
GO terms
2
Lj4g3v1260350.2
– PREDICTED: protein arginine N-methyltransferase 1.6-like [Glycine max] gi|356514280|ref|XP_003525834.1|
GO terms
2
Lj4g3v1260350.3
– PREDICTED: protein arginine N-methyltransferase 1.6-like [Glycine max] gi|356514280|ref|XP_003525834.1|
GO terms
2
Lj4g3v2315760.1
– PREDICTED: probable histone-arginine methyltransferase 1.4-like [Glycine max] gi|356564063|ref|XP_003550276.1|
GO terms
2
Lj4g3v2315760.2
– PREDICTED: probable histone-arginine methyltransferase 1.4-like [Glycine max] gi|356564063|ref|XP_003550276.1|
GO terms
2
Lj5g3v0280400.1
– PREDICTED: probable protein arginine N-methyltransferase 6-like [Glycine max] gi|356576535|ref|XP_003556386.1|
GO terms
2
Lj6g3v1445610.1
– PREDICTED: probable histone-arginine methyltransferase 1.4-like [Glycine max] gi|356556084|ref|XP_003546357.1|
GO terms
2
Lj6g3v1445610.3
– PREDICTED: probable histone-arginine methyltransferase 1.4-like [Glycine max] gi|356556084|ref|XP_003546357.1|
GO terms
2
LotjaGi1g1v0201100.1
– Protein arginine methyltransferase; TAIR: AT1G04870.2 protein arginine methyltransferase 10; Swiss-Prot: sp|Q9MAT5|ANM10_ARATH Protein arginine N-methyltransferase PRMT10; TrEMBL-Plants: tr|V7AYD9|V7AYD9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0201100
GO terms
2
LotjaGi1g1v0201100.2
– Protein arginine methyltransferase; TAIR: AT1G04870.2 protein arginine methyltransferase 10; Swiss-Prot: sp|Q9MAT5|ANM10_ARATH Protein arginine N-methyltransferase PRMT10; TrEMBL-Plants: tr|V7AYD9|V7AYD9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0201100
GO terms
2
LotjaGi1g1v0201100.3
– Protein arginine methyltransferase; TAIR: AT1G04870.2 protein arginine methyltransferase 10; Swiss-Prot: sp|Q9MAT5|ANM10_ARATH Protein arginine N-methyltransferase PRMT10; TrEMBL-Plants: tr|V7AYD9|V7AYD9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0201100
GO terms
2
LotjaGi1g1v0360600.1
– Ankyrin repeat family protein; TAIR: AT5G65860.2 ankyrin repeat family protein; Swiss-Prot: sp|P0CQ69|RMT2_CRYNB Protein arginine N-methyltransferase 2; TrEMBL-Plants: tr|A0A1J7HQ34|A0A1J7HQ34_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0360600
GO terms
1
LotjaGi1g1v0392200.1
– Protein arginine N-methyltransferase; TAIR: AT4G31120.1 SHK1 binding protein 1; Swiss-Prot: sp|Q8GWT4|ANM15_ARATH Protein arginine N-methyltransferase 1.5; TrEMBL-Plants: tr|A0A151SR51|A0A151SR51_CAJCA Protein arginine N-methyltransferase; Found in the gene: LotjaGi1g1v0392200
GO terms
2
LotjaGi2g1v0024800.1
– Protein arginine methyltransferase; TAIR: AT3G20020.1 protein arginine methyltransferase 6; Swiss-Prot: sp|Q08A71|ANM6_ARATH Probable protein arginine N-methyltransferase 6; TrEMBL-Plants: tr|I1NCV3|I1NCV3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0024800
GO terms
2
LotjaGi2g1v0024800.2
– Protein arginine methyltransferase; TAIR: AT3G20020.1 protein arginine methyltransferase 6; Swiss-Prot: sp|Q08A71|ANM6_ARATH Probable protein arginine N-methyltransferase 6; TrEMBL-Plants: tr|I3SBQ3|I3SBQ3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0024800
GO terms
2
LotjaGi2g1v0231000.1
– Protein arginine methyltransferase; TAIR: AT4G29510.1 arginine methyltransferase 11; Swiss-Prot: sp|A2Z0C0|ANM1_ORYSI Probable protein arginine N-methyltransferase 1; TrEMBL-Plants: tr|A0A0L9VGF9|A0A0L9VGF9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0231000
GO terms
2
LotjaGi2g1v0231000.2
– Protein arginine methyltransferase; TAIR: AT4G29510.1 arginine methyltransferase 11; Swiss-Prot: sp|A2Z0C0|ANM1_ORYSI Probable protein arginine N-methyltransferase 1; TrEMBL-Plants: tr|A0A0L9VGF9|A0A0L9VGF9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0231000
GO terms
2
LotjaGi2g1v0231000.3
– Protein arginine methyltransferase; TAIR: AT4G29510.1 arginine methyltransferase 11; Swiss-Prot: sp|A2Z0C0|ANM1_ORYSI Probable protein arginine N-methyltransferase 1; TrEMBL-Plants: tr|A0A0L9VGF9|A0A0L9VGF9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0231000
GO terms
2
LotjaGi3g1v0107900.1
– Protein arginine methyltransferase; TAIR: AT3G12270.1 protein arginine methyltransferase 3; Swiss-Prot: sp|Q0WVD6|ANM3_ARATH Probable protein arginine N-methyltransferase 3; TrEMBL-Plants: tr|G7IYP7|G7IYP7_MEDTR Arginine N-methyltransferase, putative; Found in the gene: LotjaGi3g1v0107900
GO terms
2
LotjaGi4g1v0203700.1
– Arginine N-methyltransferase; TAIR: AT4G16570.1 protein arginine methyltransferase 7; Swiss-Prot: sp|Q944R7|ANM16_ARATH Protein arginine N-methyltransferase 1.6; TrEMBL-Plants: tr|I1K0P7|I1K0P7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0203700
GO terms
2
LotjaGi4g1v0203700.2
– Protein arginine N-methyltransferase 7; TAIR: AT4G16570.1 protein arginine methyltransferase 7; Swiss-Prot: sp|Q944R7|ANM16_ARATH Protein arginine N-methyltransferase 1.6; TrEMBL-Plants: tr|A0A0R0JRC7|A0A0R0JRC7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0203700
GO terms
2
LotjaGi4g1v0341500.1
– Protein arginine methyltransferase; TAIR: AT5G49020.1 protein arginine methyltransferase 4A; Swiss-Prot: sp|A3KPF2|ANM14_ARATH Probable histone-arginine methyltransferase 1.4; TrEMBL-Plants: tr|I1MRI4|I1MRI4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0341500
GO terms
2
LotjaGi4g1v0341500.2
– Protein arginine methyltransferase; TAIR: AT3G06930.2 protein arginine methyltransferase 4B; Swiss-Prot: sp|Q84W92|ANM13_ARATH Probable histone-arginine methyltransferase 1.3; TrEMBL-Plants: tr|I1MRI4|I1MRI4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0341500
GO terms
2
LotjaGi6g1v0249800.1
– Protein arginine methyltransferase; TAIR: AT5G49020.1 protein arginine methyltransferase 4A; Swiss-Prot: sp|A3KPF2|ANM14_ARATH Probable histone-arginine methyltransferase 1.4; TrEMBL-Plants: tr|I1MGL5|I1MGL5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0249800
GO terms
2
LotjaGi6g1v0249800.2
– Protein arginine methyltransferase; TAIR: AT5G49020.1 protein arginine methyltransferase 4A; Swiss-Prot: sp|A3KPF2|ANM14_ARATH Probable histone-arginine methyltransferase 1.4; TrEMBL-Plants: tr|I1MGL5|I1MGL5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0249800
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0018216
Biological process Peptidyl-arginine methylation 1 3.57