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GO:0016598

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Protein arginylation
Full defintion The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.
Subterm of

Relationships

The relationship of GO:0016598 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Global analysis of posttranslational protein arginylation.Wong CC, Xu T, Rai R, Bailey AO, Yates JR 3rd, Wolf YI, Zebroski H, Kashina A
PLoS Biol. 2007 Oct; 5 (10): e258.PMID: 17896865

Posttranslational arginylation is critical for embryogenesis, cardiovascular development, and angiogenesis, but its molecular effects and the identity of proteins arginylated in vivo are largely unknown. Here we report a global analysis of this modification on the protein level and identification of 43 proteins arginylated in vivo on highly specific sites. Our data demonstrate that unlike previously believed, arginylation can occur on any N-terminally exposed residue likely defined by a structural recognition motif on the protein surface, and that it preferentially affects a number of physiological systems, including cytoskeleton and primary metabolic pathways. The results of our study suggest that protein arginylation is a general mechanism for regulation of protein structure and function and outline the potential role of protein arginylation in cell metabolism and embryonic development.

Associated Lotus transcripts 2

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi6g1v0072400.1
– Arginyl-tRNA--protein transferase; TAIR: AT5G05700.1 arginine-tRNA protein transferase 1; Swiss-Prot: sp|Q9ZT48|ATE1_ARATH Arginyl-tRNA--protein transferase 1; TrEMBL-Plants: tr|I1MZ35|I1MZ35_SOYBN Arginyl-tRNA--protein transferase; Found in the gene: LotjaGi6g1v0072400
GO terms
2
LotjaGi6g1v0072400.2
– Arginyl-tRNA--protein transferase; TAIR: AT5G05700.1 arginine-tRNA protein transferase 1; Swiss-Prot: sp|Q9ZT48|ATE1_ARATH Arginyl-tRNA--protein transferase 1; TrEMBL-Plants: tr|I1MZ35|I1MZ35_SOYBN Arginyl-tRNA--protein transferase; Found in the gene: LotjaGi6g1v0072400
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0016598
Biological process Protein arginylation 1 50.00