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GO:0016971

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Flavin-linked sulfhydryl oxidase activity
Full defintion Catalysis of the formation of disulfide bridges.
Subterm of

Relationships

The relationship of GO:0016971 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase.Lee J, Hofhaus G, Lisowsky T
FEBS Lett. 2000 Jul 14; 477 (1-2): 62–6.PMID: 10899311

The yeast ERV1 gene encodes a small polypeptide of 189 amino acids that is essential for mitochondrial function and for the viability of the cell. In this study we report the enzymatic activity of this protein as a flavin-linked sulfhydryl oxidase catalyzing the formation of disulfide bridges. Deletion of the amino-terminal part of Erv1p shows that the enzyme activity is located in the 15 kDa carboxy-terminal domain of the protein. This fragment of Erv1p still binds FAD and catalyzes the formation of disulfide bonds but is no longer able to form dimers like the complete protein. The carboxy-terminal fragment contains a conserved CXXC motif that is present in all homologous proteins from yeast to human. Thus Erv1p represents the first FAD-linked sulfhydryl oxidase from yeast and the first of these enzymes that is involved in mitochondrial biogenesis.

Associated Lotus transcripts 4

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi3g1v0138800_LC.1
– Sulfhydryl oxidase; TAIR: AT1G15020.1 quiescin-sulfhydryl oxidase 1; Swiss-Prot: sp|Q6AUC6|QSOX1_ORYSJ Sulfhydryl oxidase 1; TrEMBL-Plants: tr|I1NFT7|I1NFT7_SOYBN Sulfhydryl oxidase; Found in the gene: LotjaGi3g1v0138800_LC
GO terms
1
LotjaGi4g1v0245500.1
– Sulfhydryl oxidase; TAIR: AT1G49880.1 Erv1/Alr family protein; Swiss-Prot: sp|Q8GXX0|ERV1_ARATH FAD-linked sulfhydryl oxidase ERV1; TrEMBL-Plants: tr|A0A151SFK0|A0A151SFK0_CAJCA Sulfhydryl oxidase; Found in the gene: LotjaGi4g1v0245500
GO terms
1
LotjaGi5g1v0331700.1
– Sulfhydryl oxidase; TAIR: AT2G01270.1 quiescin-sulfhydryl oxidase 2; Swiss-Prot: sp|Q9ZU40|QSOX2_ARATH Sulfhydryl oxidase 2; TrEMBL-Plants: tr|K7LLL4|K7LLL4_SOYBN Sulfhydryl oxidase; Found in the gene: LotjaGi5g1v0331700
GO terms
1
LotjaGi5g1v0331700.2
– Sulfhydryl oxidase; TAIR: AT1G15020.2 quiescin-sulfhydryl oxidase 1; Swiss-Prot: sp|Q8W4J3|QSOX1_ARATH Sulfhydryl oxidase 1; TrEMBL-Plants: tr|A0A0B2PBV9|A0A0B2PBV9_GLYSO Sulfhydryl oxidase; Found in the gene: LotjaGi5g1v0331700
GO terms
1

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0016971
Molecular function Flavin-linked sulfhydryl oxidase activity 1 25.00