Gene Ontology — View

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GO:0030122

Overview

Field	Value
Namespace	Cellular component
Short description	AP-2 adaptor complex
Full defintion	A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
Subterm of	GO:0030131 GO:0044433 GO:0098797

Relationships

The relationship of GO:0030122 with other GO terms.

Relationship type	GO terms
Is a	GO:0030131 GO:0044433 GO:0098797
Regulates	n.a.
Part of	GO:0030128 GO:0030132
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0030122, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
GOC	mah
PMID	Review series: From uncertain beginnings: initiation mechanisms of clathrin-mediated endocytosis.Godlee C, Kaksonen M J Cell Biol. 2013 Dec 9; 203 (5): 717–25.PMID: 24322426 Clathrin-mediated endocytosis is a central and well-studied trafficking process in eukaryotic cells. How this process is initiated is likely to be a critical point in regulating endocytic activity spatially and temporally, but the underlying mechanisms are poorly understood. During the early stages of endocytosis three components-adaptor and accessory proteins, cargo, and lipids-come together at the plasma membrane to begin the formation of clathrin-coated vesicles. Although different models have been proposed, there is still no clear picture of how these three components cooperate to initiate endocytosis, which may indicate that there is some flexibility underlying this important event.

Field

Value

GOC

mah

PMID

Review series: From uncertain beginnings: initiation mechanisms of clathrin-mediated endocytosis.Godlee C, Kaksonen M
J Cell Biol. 2013 Dec 9; 203 (5): 717–25.PMID: 24322426

Clathrin-mediated endocytosis is a central and well-studied trafficking process in eukaryotic cells. How this process is initiated is likely to be a critical point in regulating endocytic activity spatially and temporally, but the underlying mechanisms are poorly understood. During the early stages of endocytosis three components-adaptor and accessory proteins, cargo, and lipids-come together at the plasma membrane to begin the formation of clathrin-coated vesicles. Although different models have been proposed, there is still no clear picture of how these three components cooperate to initiate endocytosis, which may indicate that there is some flexibility underlying this important event.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
LotjaGi3g1v0172200.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	AP-2 complex subunit alpha; TAIR: AT5G22770.1 alpha-adaptin; Swiss-Prot: sp\|Q8LPL6\|AP2A1_ARATH AP-2 complex subunit alpha-1; TrEMBL-Plants: tr\|A0A151RV94\|A0A151RV94_CAJCA AP-2 complex subunit alpha; Found in the gene: LotjaGi3g1v0172200	GO terms View details of GO:0015031 View details of GO:0030122 View details of GO:0035615 View details of GO:0072583	4
LotjaGi3g1v0172200.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	AP-2 complex subunit alpha; TAIR: AT5G22770.1 alpha-adaptin; Swiss-Prot: sp\|Q8LPL6\|AP2A1_ARATH AP-2 complex subunit alpha-1; TrEMBL-Plants: tr\|A0A151RV94\|A0A151RV94_CAJCA AP-2 complex subunit alpha; Found in the gene: LotjaGi3g1v0172200	GO terms View details of GO:0015031 View details of GO:0030122 View details of GO:0035615 View details of GO:0072583	4
LotjaGi3g1v0172200.3 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	AP-2 complex subunit alpha; TAIR: AT5G22770.1 alpha-adaptin; Swiss-Prot: sp\|Q8LPL6\|AP2A1_ARATH AP-2 complex subunit alpha-1; TrEMBL-Plants: tr\|A0A151RV94\|A0A151RV94_CAJCA AP-2 complex subunit alpha; Found in the gene: LotjaGi3g1v0172200	GO terms View details of GO:0015031 View details of GO:0030122 View details of GO:0035615 View details of GO:0072583	4

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0072583 View details of GO:0072583 AmiGO InterPro QuickGO	Biological process	Clathrin-dependent endocytosis	1	33.33