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GO:0031209

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description SCAR complex
Full defintion A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.
Subterm of

Relationships

The relationship of GO:0031209 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCpg
PMID
Biochemical reconstitution of the WAVE regulatory complex.Chen B, Padrick SB, Henry L, Rosen MK
Methods Enzymol. 2014; 540 (): 55–72.PMID: 24630101

The WAVE regulatory complex (WRC) is a 400-kDa heteropentameric protein assembly that plays a central role in controlling actin cytoskeletal dynamics in many cellular processes. The WRC acts by integrating diverse cellular cues and stimulating the actin nucleating activity of the Arp2/3 complex at membranes. Biochemical and biophysical studies of the underlying mechanisms of these processes require large amounts of purified WRC. Recent success in recombinant expression, reconstitution, purification, and crystallization of the WRC has greatly advanced our understanding of the inhibition, activation, and membrane recruitment mechanisms of this complex. But many important questions remain to be answered. Here, we summarize and update the methods developed in our laboratory, which allow reliable and flexible production of tens of milligrams of recombinant WRC of crystallographic quality, sufficient for many biochemical and structural studies.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj2g3v1467900.1
– PREDICTED: protein BRICK 1-like isoform 1 [Glycine max] gi|356496693|ref|XP_003517200.1|
GO terms
3
Lj2g3v1467910.1
–
GO terms
3
LotjaGi2g1v0330400.1
– Protein BRICK 1; TAIR: AT2G22640.1 BRICK1; Swiss-Prot: sp|Q94JY4|BRK1_ARATH Protein BRICK 1; TrEMBL-Plants: tr|A0A0B2PBB9|A0A0B2PBB9_GLYSO Protein BRICK 1; Found in the gene: LotjaGi2g1v0330400
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0044877
Molecular function Protein-containing complex binding 1 33.33