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GO:0032039

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Integrator complex
Full defintion A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.
Subterm of

Relationships

The relationship of GO:0032039 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R
Cell. 2005 Oct 21; 123 (2): 265–76.PMID: 16239144

The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is an essential component of transcriptional regulation and RNA processing of protein-coding genes. A large body of data also implicates the CTD in the transcription and processing of RNAPII-mediated small nuclear RNAs (snRNAs). However, the identity of the complex (or complexes) that associates with the CTD and mediates the processing of snRNAs has remained elusive. Here, we describe an RNA polymerase II complex that contains at least 12 novel subunits, termed the Integrator, in addition to core RNAPII subunits. Two of the Integrator subunits display similarities to the subunits of the cleavage and polyadenylation specificity factor (CPSF) complex. We show that Integrator is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The Integrator complex is evolutionarily conserved in metazoans and directly interacts with the C-terminal domain of the RNA polymerase II largest subunit.

Associated Lotus transcripts 12

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0261929.1
– PREDICTED: integrator complex subunit 9-like [Cicer arietinum] gi|502163556|ref|XP_004512875.1|
GO terms
2
Lj2g3v2902390.1
– CM0545.610.nc [Lotus japonicus] gi|164564748|dbj|BAF98228.1|
GO terms
2
LotjaGi1g1v0063600_LC.2
– Integrator complex subunit 7; TAIR: AT4G20060.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL91|INT7_CHICK Integrator complex subunit 7; TrEMBL-Plants: tr|B0BLJ3|B0BLJ3_LOTJA CM0545.590.nc protein; Found in the gene: LotjaGi1g1v0063600_LC
GO terms
2
LotjaGi1g1v0063900.1
– Integrator complex subunit 7; TAIR: AT4G20060.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL91|INT7_CHICK Integrator complex subunit 7; TrEMBL-Plants: tr|B0BLJ2|B0BLJ2_LOTJA CM0545.610.nc protein; Found in the gene: LotjaGi1g1v0063900
GO terms
2
LotjaGi1g1v0063900.2
– Integrator complex subunit 7; TAIR: AT4G20060.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL91|INT7_CHICK Integrator complex subunit 7; TrEMBL-Plants: tr|B0BLJ2|B0BLJ2_LOTJA CM0545.610.nc protein; Found in the gene: LotjaGi1g1v0063900
GO terms
2
LotjaGi1g1v0064400_LC.1
– Integrator complex subunit 7; TAIR: AT4G20060.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL91|INT7_CHICK Integrator complex subunit 7; TrEMBL-Plants: tr|B0BLJ2|B0BLJ2_LOTJA CM0545.610.nc protein; Found in the gene: LotjaGi1g1v0064400_LC
GO terms
2
LotjaGi1g1v0064500.1
– Integrator complex subunit 7; TAIR: AT4G20060.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL91|INT7_CHICK Integrator complex subunit 7; TrEMBL-Plants: tr|B0BLJ2|B0BLJ2_LOTJA CM0545.610.nc protein; Found in the gene: LotjaGi1g1v0064500
GO terms
2
LotjaGi1g1v0064500.2
– Integrator complex subunit 7; TAIR: AT4G20060.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL91|INT7_CHICK Integrator complex subunit 7; TrEMBL-Plants: tr|B0BLJ2|B0BLJ2_LOTJA CM0545.610.nc protein; Found in the gene: LotjaGi1g1v0064500
GO terms
2
LotjaGi3g1v0112900.1
– Integrator complex subunit-like protein; TAIR: AT3G07530.2 integrator complex subunit; Swiss-Prot: sp|A7SBF0|INT9_NEMVE Integrator complex subunit 9 homolog; TrEMBL-Plants: tr|A0A1J7GXA9|A0A1J7GXA9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0112900
GO terms
2
LotjaGi3g1v0112900.2
– Integrator complex subunit-like protein; TAIR: AT3G07530.2 integrator complex subunit; Swiss-Prot: sp|A7SBF0|INT9_NEMVE Integrator complex subunit 9 homolog; TrEMBL-Plants: tr|A0A1J7GXA9|A0A1J7GXA9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0112900
GO terms
2
LotjaGi3g1v0112900.3
– Integrator complex subunit-like protein; TAIR: AT3G07530.2 integrator complex subunit; Swiss-Prot: sp|A7SBF0|INT9_NEMVE Integrator complex subunit 9 homolog; TrEMBL-Plants: tr|A0A1J7GXA9|A0A1J7GXA9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0112900
GO terms
2
LotjaGi3g1v0453300_LC.1
– Integrator complex subunit 7; TAIR: AT4G20060.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q5ZL91|INT7_CHICK Integrator complex subunit 7; TrEMBL-Plants: tr|B0BLJ2|B0BLJ2_LOTJA CM0545.610.nc protein; Found in the gene: LotjaGi3g1v0453300_LC
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0032039
Cellular component Integrator complex 1 8.33