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Field | Value |
---|---|
Namespace | Cellular component |
Short description | Rad51B-Rad51C-Rad51D-XRCC2 complex |
Full defintion | A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof. |
Subterm of |
The relationship of GO:0033063 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0033063, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | mah |
PMID | Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J Biol Chem. 2007 Jan 19; 282 (3): 1973–9.PMID: 17114795 In germ line cells, recombination is required for gene reassortment and proper chromosome segregation at meiosis, whereas in somatic cells it provides an important mechanism for the repair of DNA double-strand breaks. Five proteins (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) that share homology with RAD51 recombinase and are known as the RAD51 paralogs are important for recombinational repair, as paralog-defective cell lines exhibit spontaneous chromosomal aberrations, defective DNA repair, and reduced gene targeting. The paralogs form two distinct protein complexes, RAD51B-RAD51C-RAD51D-XRCC2 and RAD51C-XRCC3, but their precise cellular roles remain unknown. Here, we show that, like MLH1, RAD51C localized to mouse meiotic chromosomes at pachytene/diplotene. Using immunoprecipitation and gel filtration analyses, we found that Holliday junction resolvase activity associated tightly and co-eluted with the 80-kDa RAD51C-XRCC3 complex. Taken together, these data indicate that the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: DNA repair protein RAD51 homolog 2-like isoform X1 [Cicer arietinum] gi|502082384|ref|XP_004487150.1| | 4 | ||
– | PREDICTED: DNA repair protein RAD51 homolog 2-like isoform X1 [Cicer arietinum] gi|502082384|ref|XP_004487150.1| | 4 | ||
– | PREDICTED: DNA repair protein RAD51 homolog 2-like isoform X1 [Cicer arietinum] gi|502082384|ref|XP_004487150.1| | 4 | ||
– | DNA repair RAD51-like protein; TAIR: AT2G28560.2 DNA repair (Rad51) family protein; Swiss-Prot: sp|Q9SK02|RA51B_ARATH DNA repair protein RAD51 homolog 2; TrEMBL-Plants: tr|A0A0S3SGI1|A0A0S3SGI1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0269600 | 4 | ||
– | DNA repair RAD51-like protein; TAIR: AT2G28560.2 DNA repair (Rad51) family protein; Swiss-Prot: sp|Q9SK02|RA51B_ARATH DNA repair protein RAD51 homolog 2; TrEMBL-Plants: tr|A0A0S3SGI1|A0A0S3SGI1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0269600 | 4 | ||
– | DNA repair protein XRCC2 like; TAIR: AT5G64520.5 homolog of X-ray repair cross complementing 2 (XRCC2); Swiss-Prot: sp|Q682D3|XRCC2_ARATH DNA repair protein XRCC2 homolog; TrEMBL-Plants: tr|A0A072UXF4|A0A072UXF4_MEDTR X-ray repair cross complementing 2 (XRCC2)-like protein, putative; Found in the gene: LotjaGi3g1v0525200 | 4 | ||
– | DNA repair protein XRCC2 like; TAIR: AT5G64520.5 homolog of X-ray repair cross complementing 2 (XRCC2); Swiss-Prot: sp|Q682D3|XRCC2_ARATH DNA repair protein XRCC2 homolog; TrEMBL-Plants: tr|A0A072UXF4|A0A072UXF4_MEDTR X-ray repair cross complementing 2 (XRCC2)-like protein, putative; Found in the gene: LotjaGi3g1v0525200 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Cellular component | Rad51B-Rad51C-Rad51D-XRCC2 complex | 1 | 14.29 |