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Field | Value |
---|---|
Namespace | Biological process |
Short description | Proteasome assembly |
Full defintion | The aggregation, arrangement and bonding together of a mature, active proteasome complex. |
Subterm of |
The relationship of GO:0043248 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0043248, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
GOC | go_curators |
PMID | The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem. 1999; 68 (): 1015–68.PMID: 10872471 In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built from approximately 31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. The regulatory complexes are also implicated in unfolding and translocation of ubiquitinated targets into the interior of the 20S complex, where they are degraded to oligopeptides. Structure, assembly and enzymatic mechanism of the 20S complex have been elucidated, but the functional organization of the 19S complex is less well understood. Most subunits of the 19S complex have been identified, however, specific functions have been assigned to only a few. A low-resolution structure of the 26S proteasome has been obtained by electron microscopy, but the precise arrangement of subunits in the 19S complex is unclear. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: probable 26S proteasome complex subunit sem1-1 [Glycine max] gi|356508661|ref|XP_003523073.1| | 3 | ||
– | PREDICTED: probable 26S proteasome complex subunit sem1-1 [Glycine max] gi|356508661|ref|XP_003523073.1| | 3 | ||
– | PREDICTED: cyclin-B1-2-like [Cicer arietinum] gi|502159298|ref|XP_004511459.1| | 1 | ||
– | PREDICTED: LOW QUALITY PROTEIN: proteasome-associated protein ECM29 homolog [Cicer arietinum] gi|502098370|ref|XP_004491219.1| | 2 | ||
– | PREDICTED: LOW QUALITY PROTEIN: proteasome-associated protein ECM29 homolog [Cicer arietinum] gi|502098370|ref|XP_004491219.1| | 2 | ||
– | 26S proteasome non-ATPase regulatory subunit [Medicago truncatula] gi|357516527|ref|XP_003628552.1| | 1 | ||
– | PREDICTED: cyclin-B1-2-like [Glycine max] gi|356543516|ref|XP_003540206.1| | 1 | ||
– | PREDICTED: proteasome assembly chaperone 4-like [Fragaria vesca subsp]. vesca] gi|470122119|ref|XP_004297097.1| | 1 | ||
– | Proteasome-associated ECM29-like protein; TAIR: AT2G26780.2 ARM repeat superfamily protein; Swiss-Prot: sp|Q5VYK3|ECM29_HUMAN Proteasome-associated protein ECM29 homolog; TrEMBL-Plants: tr|G7KCU1|G7KCU1_MEDTR Proteasome-associated ECM29-like protein; Found in the gene: LotjaGi1g1v0052500 | 2 | ||
– | Proteasome maturation factor UMP1 family protein; TAIR: AT5G38650.1 Proteasome maturation factor UMP1; Swiss-Prot: sp|Q0DWQ7|CCB12_ORYSJ Cyclin-B1-2; TrEMBL-Plants: tr|I3T380|I3T380_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0447800 | 1 | ||
– | ARM repeat superfamily protein; TAIR: AT3G15180.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q0P5A6|PSMD5_BOVIN 26S proteasome non-ATPase regulatory subunit 5; TrEMBL-Plants: tr|I1KDR0|I1KDR0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0045000 | 1 | ||
– | Proteasome maturation factor UMP1 family protein; TAIR: AT1G67250.1 Proteasome maturation factor UMP1; Swiss-Prot: sp|Q0DWQ7|CCB12_ORYSJ Cyclin-B1-2; TrEMBL-Plants: tr|I3SXF4|I3SXF4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0537400 | 1 | ||
– | Proteasome assembly chaperone 4; TAIR: AT1G48170.1 proteasome assembly chaperone; Swiss-Prot: sp|Q5JS54|PSMG4_HUMAN Proteasome assembly chaperone 4; TrEMBL-Plants: tr|I3S521|I3S521_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0216900 | 1 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Proteasome assembly | 1 | 7.69 |