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GO:0046429

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
Full defintion Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin.
Subterm of

Relationships

The relationship of GO:0046429 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
EC1.17.7.1
PMID
Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein.Hecht S, Eisenreich W, Adam P, Amslinger S, Kis K, Bacher A, Arigoni D, Rohdich F
Proc Natl Acad Sci U S A. 2001 Dec 18; 98 (26): 14837–42.PMID: 11752431

Recombinant Escherichia coli cells engineered for the expression of the xylB gene in conjunction with genes of the nonmevalonate pathway were supplied with (13)C-labeled 1-deoxy-D-xylulose. Cell extracts were analyzed directly by NMR spectroscopy. (13)C-labeled 2C-methyl-D-erythritol 2,4-cyclodiphosphate was detected at high levels in cells expressing xylB, ispC, ispD, ispE, and ispF. The additional expression of the gcpE gene afforded 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate as an intermediate of the nonmevalonate pathway. Hypothetical mechanisms involving conserved cysteine residues are proposed for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate catalyzed by the GcpE protein.

Associated Lotus transcripts 6

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v1049420.1
– PREDICTED: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase-like [Glycine max] gi|356550161|ref|XP_003543457.1|
GO terms
5
Lj1g3v1049420.2
– PREDICTED: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase-like [Glycine max] gi|356550161|ref|XP_003543457.1|
GO terms
3
LotjaGi3g1v0162300.1
– 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300
GO terms
5
LotjaGi3g1v0162300.2
– 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300
GO terms
5
LotjaGi3g1v0162300.3
– 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|I1M4L1|I1M4L1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0162300
GO terms
5
LotjaGi3g1v0162300.4
– 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); TAIR: AT5G60600.1 4-hydroxy-3-methylbut-2-enyl diphosphate synthase; Swiss-Prot: sp|F4K0E8|ISPG_ARATH 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic; TrEMBL-Plants: tr|A0A151RCK5|A0A151RCK5_CAJCA 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Found in the gene: LotjaGi3g1v0162300
GO terms
5

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0055114
Biological process Oxidation-reduction process 1 16.67