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Field | Value |
---|---|
Namespace | Cellular component |
Short description | Set1C/COMPASS complex |
Full defintion | A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. |
Subterm of |
The relationship of GO:0048188 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0048188, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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PMID | Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol. 2008 Dec; 28 (24): 7337–44.PMID: 18838538 In yeast, the macromolecular complex Set1/COMPASS is capable of methylating H3K4, a posttranslational modification associated with actively transcribed genes. There is only one Set1 in yeast; yet in mammalian cells there are multiple H3K4 methylases, including Set1A/B, forming human COMPASS complexes, and MLL1-4, forming human COMPASS-like complexes. We have shown that Wdr82, which associates with chromatin in a histone H2B ubiquitination-dependent manner, is a specific component of Set1 complexes but not that of MLL1-4 complexes. RNA interference-mediated knockdown of Wdr82 results in a reduction in the H3K4 trimethylation levels, although these cells still possess active MLL complexes. Comprehensive in vitro enzymatic studies with Set1 and MLL complexes demonstrated that the Set1 complex is a more robust H3K4 trimethylase in vitro than the MLL complexes. Given our in vivo and in vitro observations, it appears that the human Set1 complex plays a more widespread role in H3K4 trimethylation than do the MLL complexes in mammalian cells. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Retinoblastoma-binding-like protein; TAIR: AT3G21060.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q5E915|RBBP_ARATH Protein RBL; TrEMBL-Plants: tr|I3SQI4|I3SQI4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0100700 | 1 | ||
– | Retinoblastoma-binding protein 5; TAIR: AT3G21060.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q5E915|RBBP_ARATH Protein RBL; TrEMBL-Plants: tr|I3SQI4|I3SQI4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0100700 | 1 | ||
– | Retinoblastoma-binding protein 5; TAIR: AT3G21060.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q5E915|RBBP_ARATH Protein RBL; TrEMBL-Plants: tr|I3SQI4|I3SQI4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0100700 | 1 | ||
– | Retinoblastoma-binding-like protein; TAIR: AT3G21060.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q5E915|RBBP_ARATH Protein RBL; TrEMBL-Plants: tr|I3SQI4|I3SQI4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0100700 | 1 | ||
– | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|I1LPA8|I1LPA8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 2 | ||
– | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|V7ADB2|V7ADB2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Histone H3-K4 methylation | 1 | 16.67 |