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Field | Value |
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Namespace | Molecular function |
Short description | ADP-dependent NAD(P)H-hydrate dehydratase activity |
Full defintion | Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate. |
Subterm of |
The relationship of GO:0052855 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0052855, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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EC | 4.2.1.93 |
PMID | Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. J Biol Chem. 2011 Dec 2; 286 (48): 41246–41252.PMID: 21994945 The reduced forms of NAD and NADP, two major nucleotides playing a central role in metabolism, are continuously damaged by enzymatic or heat-dependent hydration. We report the molecular identification of the eukaryotic dehydratase that repairs these nucleotides and show that this enzyme (Carkd in mammals, YKL151C in yeast) catalyzes the dehydration of the S form of NADHX and NADPHX, at the expense of ATP, which is converted to ADP. Surprisingly, the Escherichia coli homolog, YjeF, a bidomain protein, catalyzes a similar reaction, but using ADP instead of ATP. The latter reaction is ascribable to the C-terminal domain of YjeF. This represents an unprecedented example of orthologous enzymes using either ADP or ATP as phosphoryl donor. We also show that eukaryotic proteins homologous to the N-terminal domain of YjeF (apolipoprotein A-1-binding protein (AIBP) in mammals, YNL200C in yeast) catalyze the epimerization of the S and R forms of NAD(P)HX, thereby allowing, in conjunction with the energy-dependent dehydratase, the repair of both epimers of NAD(P)HX. Both enzymes are very widespread in eukaryotes, prokaryotes, and archaea, which together with the ADP dependence of the dehydratase in some species indicates the ancient origin of this repair system. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | 1 | |||
– | PREDICTED: ATP-dependent (S)-NAD(P)H-hydrate dehydratase-like isoform X2 [Cicer arietinum] gi|502079057|ref|XP_004486140.1| | 1 | ||
– | Malic enzyme; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|A0A151STR1|A0A151STR1_CAJCA ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi3g1v0121300_LC | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|A0A072VF60|A0A072VF60_MEDTR ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0297100 | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|A0A072VF60|A0A072VF60_MEDTR ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0297100 | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|M5XX22|M5XX22_PRUPE ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0351300_LC | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|A0A0B2P102|A0A0B2P102_GLYSO ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0351300_LC | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|M5XX22|M5XX22_PRUPE ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0351300_LC | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|A0A0B2P102|A0A0B2P102_GLYSO ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0351300_LC | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|M5XX22|M5XX22_PRUPE ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0351300_LC | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|I1KNA0|I1KNA0_SOYBN ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0351300_LC | 1 | ||
– | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TAIR: AT5G19150.1 pfkB-like carbohydrate kinase family protein; Swiss-Prot: sp|F6HDM2|NNRD_VITVI ATP-dependent (S)-NAD(P)H-hydrate dehydratase; TrEMBL-Plants: tr|M5XX22|M5XX22_PRUPE ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Found in the gene: LotjaGi6g1v0351300_LC | 1 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Molecular function | ADP-dependent NAD(P)H-hydrate dehydratase activity | 1 | 8.33 |