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Field | Value |
---|---|
Namespace | Molecular function |
Short description | Lys63-specific deubiquitinase activity |
Full defintion | Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. |
Subterm of |
The relationship of GO:0061578 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0061578, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
GOC | pg |
PMID | The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. Mol Cell. 2008 Feb 29; 29 (4): 451–64.PMID: 18313383 The tumor suppressor CYLD antagonizes NF-kappaB and JNK signaling by disassembly of Lys63-linked ubiquitin chains synthesized in response to cytokine stimulation. Here we describe the crystal structure of the CYLD USP domain, revealing a distinctive architecture that provides molecular insights into its specificity toward Lys63-linked polyubiquitin. We identify regions of the USP domain responsible for this specificity and demonstrate endodeubiquitinase activity toward such chains. Pathogenic truncations of the CYLD C terminus, associated with the hypertrophic skin tumor cylindromatosis, disrupt the USP domain, accounting for loss of CYLD catalytic activity. A small zinc-binding B box domain, similar in structure to other crossbrace Zn-binding folds--including the RING domain found in E3 ubiquitin ligases--is inserted within the globular core of the USP domain. Biochemical and functional characterization of the B box suggests a role as a protein-interaction module that contributes to determining the subcellular localization of CYLD. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | 26S proteasome regulatory subunit; TAIR: AT5G23540.1 Mov34/MPN/PAD-1 family protein; Swiss-Prot: sp|Q9LT08|PSDE_ARATH 26S proteasome non-ATPase regulatory subunit 14 homolog; TrEMBL-Plants: tr|A0A1J7HGT4|A0A1J7HGT4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0025800 | 2 | ||
– | 26S proteasome regulatory subunit; TAIR: AT5G23540.1 Mov34/MPN/PAD-1 family protein; Swiss-Prot: sp|Q9LT08|PSDE_ARATH 26S proteasome non-ATPase regulatory subunit 14 homolog; TrEMBL-Plants: tr|A0A022R2G9|A0A022R2G9_ERYGU Uncharacterized protein; Found in the gene: LotjaGi6g1v0316900 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Molecular function | Lys63-specific deubiquitinase activity | 1 | 50.00 |