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GO:0070772

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description PAS complex
Full defintion A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
Subterm of

Relationships

The relationship of GO:0070772 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
A protein complex that regulates PtdIns(3,5)P2 levels.Michell RH, Dove SK
EMBO J. 2009 Jan 21; 28 (2): 86–7.PMID: 19158662

Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is needed for retrograde membrane trafficking from lysosomal and late endosomal compartments and its synthesis is tightly regulated. But how cells regulate PtdIns(3,5)P2 synthesis--for example, in response to hyperosmotic shock--remains unexplained. A paper from the Weisman group gives the most complete picture so far of a multiprotein complex that controls PtdIns(3,5)P2 synthesis and explains how a VAC14 mutation functionally impairs the scaffold protein at the heart of the complex and causes a neurodegenerative condition in mice.

Associated Lotus transcripts 20

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0006439.1
– PREDICTED: protein VAC14 homolog [Cicer arietinum] gi|502123772|ref|XP_004498253.1|
GO terms
2
Lj4g3v3113090.1
– PREDICTED: protein VAC14 homolog [Glycine max] gi|356524533|ref|XP_003530883.1|
GO terms
2
LotjaGi1g1v0265500.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
GO terms
2
LotjaGi1g1v0265500.2
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
GO terms
2
LotjaGi1g1v0265500.3
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
GO terms
2
LotjaGi1g1v0265500.4
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
GO terms
2
LotjaGi1g1v0265500.5
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi1g1v0265500
GO terms
2
LotjaGi2g1v0071300.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
GO terms
2
LotjaGi2g1v0071300.2
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
GO terms
2
LotjaGi2g1v0071300.3
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
GO terms
2
LotjaGi2g1v0071300.4
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi2g1v0071300
GO terms
2
LotjaGi2g1v0071300.5
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|I1JDH1|I1JDH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0071300
GO terms
2
LotjaGi3g1v0222300.1
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A067L1Z3|A0A067L1Z3_JATCU Uncharacterized protein; Found in the gene: LotjaGi3g1v0222300
GO terms
2
LotjaGi3g1v0243000.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi3g1v0243000
GO terms
2
LotjaGi4g1v0457000.1
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000
GO terms
2
LotjaGi4g1v0457000.2
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000
GO terms
2
LotjaGi4g1v0457000.3
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A0B2Q990|A0A0B2Q990_GLYSO Protein VAC14 like; Found in the gene: LotjaGi4g1v0457000
GO terms
2
LotjaGi4g1v0457000.5
– Protein VAC14 like; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A1J7GNE8|A0A1J7GNE8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0457000
GO terms
2
LotjaGi6g1v0173200.1
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi6g1v0173200
GO terms
2
LotjaGi6g1v0173200.2
– VAC14-like protein; TAIR: AT2G01690.1 ARM repeat superfamily protein; Swiss-Prot: sp|Q9ZU97|VAC14_ARATH Protein VAC14 homolog; TrEMBL-Plants: tr|A0A072VR25|A0A072VR25_MEDTR VAC14-like protein; Found in the gene: LotjaGi6g1v0173200
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0070772
Cellular component PAS complex 1 5.00