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Field | Value |
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Namespace | Cellular component |
Short description | ER membrane protein complex |
Full defintion | A transmembrane protein complex located in the ER that is involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. |
Subterm of |
The relationship of GO:0072546 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0072546, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | vw |
PMID | A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. PLoS Biol. 2014 Oct; 12 (10): e1001969.PMID: 25313861 Mitochondrial membrane biogenesis and lipid metabolism require phospholipid transfer from the endoplasmic reticulum (ER) to mitochondria. Transfer is thought to occur at regions of close contact of these organelles and to be nonvesicular, but the mechanism is not known. Here we used a novel genetic screen in S. cerevisiae to identify mutants with defects in lipid exchange between the ER and mitochondria. We show that a strain missing multiple components of the conserved ER membrane protein complex (EMC) has decreased phosphatidylserine (PS) transfer from the ER to mitochondria. Mitochondria from this strain have significantly reduced levels of PS and its derivative phosphatidylethanolamine (PE). Cells lacking EMC proteins and the ER-mitochondria tethering complex called ERMES (the ER-mitochondria encounter structure) are inviable, suggesting that the EMC also functions as a tether. These defects are corrected by expression of an engineered ER-mitochondrial tethering protein that artificially tethers the ER to mitochondria. EMC mutants have a significant reduction in the amount of ER tethered to mitochondria even though ERMES remained intact in these mutants, suggesting that the EMC performs an additional tethering function to ERMES. We find that all Emc proteins interact with the mitochondrial translocase of the outer membrane (TOM) complex protein Tom5 and this interaction is important for PS transfer and cell growth, suggesting that the EMC forms a tether by associating with the TOM complex. Together, our findings support that the EMC tethers ER to mitochondria, which is required for phospholipid synthesis and cell growth. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: ER membrane protein complex subunit 6-like isoform X3 [Cicer arietinum] gi|502080345|ref|XP_004486534.1| | 3 | ||
– | PREDICTED: ER membrane protein complex subunit 8/9 homolog [Cicer arietinum] gi|502099626|ref|XP_004491524.1| | 1 | ||
– | PREDICTED: ER membrane protein complex subunit 1-like [Cicer arietinum] gi|502131970|ref|XP_004501175.1| | 1 | ||
– | PREDICTED: ER membrane protein complex subunit 8/9 homolog [Cicer arietinum] gi|502099626|ref|XP_004491524.1| | 1 | ||
– | PREDICTED: ER membrane protein complex subunit 1-like [Cicer arietinum] gi|502131970|ref|XP_004501175.1| | 1 | ||
– | ER membrane protein complex subunit 8; TAIR: AT5G55940.1 Uncharacterized protein family (UPF0172); Swiss-Prot: sp|Q9FG71|EMC89_ARATH ER membrane protein complex subunit 8/9 homolog; TrEMBL-Plants: tr|I3S6K8|I3S6K8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0014900 | 1 | ||
– | ER membrane protein complex subunit 8; TAIR: AT5G55940.1 Uncharacterized protein family (UPF0172); Swiss-Prot: sp|Q9FG71|EMC89_ARATH ER membrane protein complex subunit 8/9 homolog; TrEMBL-Plants: tr|I3S6K8|I3S6K8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0014900 | 1 | ||
– | ER membrane protein complex subunit 1; TAIR: AT5G11560.1 catalytics; Swiss-Prot: sp|Q5ZL00|EMC1_CHICK ER membrane protein complex subunit 1; TrEMBL-Plants: tr|A0A072V2Z0|A0A072V2Z0_MEDTR ER membrane protein complex subunit-like protein; Found in the gene: LotjaGi1g1v0401700 | 1 | ||
– | ER membrane protein complex subunit 1; TAIR: AT5G11560.1 catalytics; Swiss-Prot: sp|F8GAQ8|BAMB_FRAST Outer membrane protein assembly factor BamB; TrEMBL-Plants: tr|I1JUT9|I1JUT9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0126300_LC | 1 | ||
– | ER membrane protein complex subunit 8/9-like protein; TAIR: AT5G55940.1 Uncharacterized protein family (UPF0172); Swiss-Prot: sp|Q9FG71|EMC89_ARATH ER membrane protein complex subunit 8/9 homolog; TrEMBL-Plants: tr|I3S6K8|I3S6K8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0236700 | 1 | ||
– | ER membrane protein complex subunit 6; TAIR: AT5G49540.1 Rab5-interacting family protein; Swiss-Prot: sp|Q1ZXH4|EMC6_DICDI ER membrane protein complex subunit 6; TrEMBL-Plants: tr|C6SYQ2|C6SYQ2_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0261100 | 3 | ||
– | ER membrane protein complex subunit 6; TAIR: AT5G49540.1 Rab5-interacting family protein; Swiss-Prot: sp|Q3ZCG8|EMC6_BOVIN ER membrane protein complex subunit 6; TrEMBL-Plants: tr|A0A151T672|A0A151T672_CAJCA Transmembrane protein 93; Found in the gene: LotjaGi6g1v0261100 | 3 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
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Cellular component | ER membrane protein complex | 1 | 8.33 |