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GO:0097255

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description R2TP complex
Full defintion A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.
Subterm of

Relationships

The relationship of GO:0097255 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCmcc
PMID
The R2TP complex: discovery and functions.Kakihara Y, Houry WA
Biochim Biophys Acta. 2012 Jan; 1823 (1): 101–7.PMID: 21925213

The two closely related AAA+family ATPases Rvb1 and Rvb2 are part of several critical multiprotein complexes, and, thus, are involved in a wide range of cellular processes including chromatin remodelling, telomerase assembly, and snoRNP biogenesis. It was found that Rvb1 and Rvb2 form a tight functional complex with Pih1 (Protein interacting with Hsp90) and Tah1 (TPR-containing protein associated with Hsp90), which are two Hsp90 interactors. We named the complex R2TP. The complex was originally isolated from Saccharomyces cerevisiae and was, subsequently, identified in mammalian cells. R2TP was found to be required for box C/D snoRNP biogenesis in yeast and mammalian cells. More recently, several studies revealed that the complex is also involved in multiple biological processes including apoptosis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signalling, and RNA polymerase II assembly. In this review, we describe the discovery of the complex and discuss the emerging critical roles that R2TP plays in distinct cellular processes.

Associated Lotus transcripts 15

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi1g1v0016800.1
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
GO terms
4
LotjaGi1g1v0016800.2
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
GO terms
4
LotjaGi1g1v0016800.3
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|Q9M3Z6|Q9M3Z6_CICAR RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
GO terms
4
LotjaGi1g1v0016800.4
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0016800
GO terms
4
LotjaGi1g1v0240100_LC.1
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|P0CR29|RUVB2_CRYNB RuvB-like helicase 2; TrEMBL-Plants: tr|B9IFT1|B9IFT1_POPTR RuvB-like helicase; Found in the gene: LotjaGi1g1v0240100_LC
GO terms
4
LotjaGi1g1v0240100_LC.2
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|P0CR29|RUVB2_CRYNB RuvB-like helicase 2; TrEMBL-Plants: tr|B9IFT1|B9IFT1_POPTR RuvB-like helicase; Found in the gene: LotjaGi1g1v0240100_LC
GO terms
4
LotjaGi1g1v0240100_LC.3
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|P0CR29|RUVB2_CRYNB RuvB-like helicase 2; TrEMBL-Plants: tr|B9IFT1|B9IFT1_POPTR RuvB-like helicase; Found in the gene: LotjaGi1g1v0240100_LC
GO terms
4
LotjaGi1g1v0425600.1
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
GO terms
4
LotjaGi1g1v0425600.2
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
GO terms
4
LotjaGi1g1v0425600.3
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
GO terms
4
LotjaGi1g1v0425600.4
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi1g1v0425600
GO terms
4
LotjaGi1g1v0425600.5
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|A0A1J7HT38|A0A1J7HT38_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0425600
GO terms
4
LotjaGi4g1v0370900_LC.1
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi4g1v0370900_LC
GO terms
4
LotjaGi4g1v0370900_LC.2
– RuvB-like helicase; TAIR: AT5G22330.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9FMR9|RIN1_ARATH RuvB-like protein 1; TrEMBL-Plants: tr|K7KZ42|K7KZ42_SOYBN RuvB-like helicase; Found in the gene: LotjaGi4g1v0370900_LC
GO terms
4
LotjaGi6g1v0135200.1
– RuvB-like helicase; TAIR: AT5G67630.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9DE27|RUVB2_XENLA RuvB-like 2; TrEMBL-Plants: tr|G7J268|G7J268_MEDTR RuvB-like helicase; Found in the gene: LotjaGi6g1v0135200
GO terms
4

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0097255
Cellular component R2TP complex 1 6.67