Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

GO:1904031

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Positive regulation of cyclin-dependent protein kinase activity
Full defintion Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity.
Subterm of

Relationships

The relationship of GO:1904031 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:1904031, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

  • Drag and drop nodes to manually position (i.e. fix) them
  • Double click on a node to unfix the node
  • Press Alt and double click to visit the page containing further details of a GO term
  • Right clicking on a node will reveal a context menu

Controls

Force layout

Every force layout is different—we have picked a set of parameters which suits most GO ancestor tree chart well. If you mess something up—don't worry: hitting the "reset view" button above will reset the chart to its default layout.

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCTermGenie
GO_REF0000059
PMID
STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans CB
Neurosci Lett. 2012 Oct 24; 528 (2): 104–9.PMID: 22995177

Intraneuronal fibrillary tangles are a major hallmark of several neurodegenerative diseases including Alzheimer's disease. The major constituents of these hallmarks are hyper-phosphorylated tau. In this study we used a neuronal cellular model which over-expresses transcription factor STOX1A in combination with the longest human tau isoform to test the effect of STOX1A on tau phosphorylation. Our results show that STOX1A induces phosphorylation of the longest human tau isoform at phospho-epitopes typically found in neurofibrillary tangles in Alzheimer's disease. In conclusion, our results show a STOX1A-dependent effect on tau phosphorylation found in neurodegenerative diseases such as Alzheimer's disease.

Associated Lotus transcripts

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

No transcripts are associated with this gene ontology identifier.