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GO:1904833

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Positive regulation of removal of superoxide radicals
Full defintion Any process that activates or increases the frequency, rate or extent of removal of superoxide radicals.
Subterm of

Relationships

The relationship of GO:1904833 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCTermGenie
GO_REF0000058
PMID
MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNFα.Zhang X, Ng WL, Wang P, Tian L, Werner E, Wang H, Doetsch P, Wang Y
Cancer Res. 2012 Sep 15; 72 (18): 4707–13.PMID: 22836756

MicroRNA-21 (miR-21) is an oncomir overexpressed in most human tumors in that it promotes malignant growth and progression by acting on multiple targets. Here, we broaden the impact of miR-21 in cancer by showing that it regulates the formation of reactive oxygen species (ROS) that promote tumorigenesis. Key targets of miR-21 in mediating this function were SOD3 and TNFα. We found that miR-21 inhibited the metabolism of superoxide to hydrogen peroxide, produced either by endogenous basal activities or exposure to ionizing radiation (IR), by directing attenuating SOD3 or by an indirect mechanism that limited TNFa production, thereby reducing SOD2 levels. Importantly, both effects contributed to an elevation of IR-induced cell transformation. Our findings, therefore, establish that miR-21 promotes tumorigenesis to a large extent through its regulation of cellular ROS levels.

Associated Lotus transcripts

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

No transcripts are associated with this gene ontology identifier.