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GO:1905775

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Negative regulation of DNA helicase activity
Full defintion Any process that stops, prevents or reduces the frequency, rate or extent of DNA helicase activity.
Subterm of

Relationships

The relationship of GO:1905775 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCTermGenie
GO_REF0000059
PMID
Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1.Ghosh A, Rossi ML, Aulds J, Croteau D, Bohr VA
J Biol Chem. 2009 Nov 6; 284 (45): 31074–84.PMID: 19734539

8-Oxo-2'-deoxyguanosine (8-oxodG) is one of the most important oxidative DNA lesions, and G-rich telomeric DNA is especially susceptible to oxidative DNA damage. RecQ helicases WRN and BLM and telomere-binding protein POT1 are thought to play roles in telomere maintenance. This study examines the ability of WRN, BLM, and RecQ5 to unwind and POT1 to bind telomeric D-loops containing 8-oxodG. The results demonstrate that WRN and BLM preferentially unwind telomeric D-loops containing 8-oxodG and that POT1 binds with higher affinity to telomeric D-loops with 8-oxodG but shows no preference for telomeric single-stranded DNA with 8-oxodG. We speculate that telomeric D-loops with 8-oxodG may have a greater tendency to form G-quadruplex DNA structures than telomeric DNA lacking 8-oxodG.

Associated Lotus transcripts 2

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj4g3v2263980.1
– PREDICTED: DNA replication licensing factor mcm2-like [Glycine max] gi|356521757|ref|XP_003529518.1|
GO terms
6
LotjaGi4g1v0332400.1
– DNA helicase; TAIR: AT1G44900.1 minichromosome maintenance (MCM2/3/5) family protein; Swiss-Prot: sp|B8BKI8|MCM2_ORYSI DNA replication licensing factor MCM2; TrEMBL-Plants: tr|V7C891|V7C891_PHAVU DNA helicase; Found in the gene: LotjaGi4g1v0332400
GO terms
6

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:1905775
Biological process Negative regulation of DNA helicase activity 1 50.00