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IPR000682 is a Protein-L-isoaspartate(D-aspartate) O-methyltransferase.
<p>Protein-L-isoaspartate(D-aspartate) O-methyltransferase ([ec:2.1.1.77]) (PCMT) [[cite:PUB00000999]] (which is also known as L-isoaspartyl protein carboxyl methyltransferase) is an enzyme that catalyses the transfer of a methyl group from S-adenosylmethionine to the free carboxyl groups of D-aspartyl or L-isoaspartyl residues in a variety of peptides and proteins. The enzyme does not act on normal L-aspartyl residues L-isoaspartyl and D-aspartyl are the products of the spontaneous deamidation and/or isomerisation of normal L-aspartyl and L-asparaginyl residues in proteins. PCMT plays a role in the repair and/or degradation of these damaged proteins; the enzymatic methyl esterification of the abnormal residues can lead to their conversion to normal L-aspartyl residues. The SAM domain is present in most of these proteins.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. | ||
Biological process | Cellular protein modification process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: protein-L-isoaspartate O-methyltransferase-like [Glycine max] gi|356508746|ref|XP_003523115.1| | 9 | ||
– | PREDICTED: protein-L-isoaspartate O-methyltransferase-like isoform X1 [Cicer arietinum] gi|502176346|ref|XP_004515853.1| | 9 | ||
– | Protein-L-isoaspartate O-methyltransferase; TAIR: AT3G48330.4 protein-l-isoaspartate methyltransferase 1; Swiss-Prot: sp|Q42539|PIMT1_ARATH Protein-L-isoaspartate O-methyltransferase 1; TrEMBL-Plants: tr|A0A0B2P8Z6|A0A0B2P8Z6_GLYSO Protein-L-isoaspartate O-methyltransferase; Found in the gene: LotjaGi1g1v0229100 | 10 | ||
– | Protein-L-isoaspartate O-methyltransferase; TAIR: AT3G48330.4 protein-l-isoaspartate methyltransferase 1; Swiss-Prot: sp|Q42539|PIMT1_ARATH Protein-L-isoaspartate O-methyltransferase 1; TrEMBL-Plants: tr|I3S6G7|I3S6G7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0226600 | 9 | ||
– | Protein-L-isoaspartate O-methyltransferase; TAIR: AT3G48330.1 protein-l-isoaspartate methyltransferase 1; Swiss-Prot: sp|Q42539|PIMT1_ARATH Protein-L-isoaspartate O-methyltransferase 1; TrEMBL-Plants: tr|I3S6G7|I3S6G7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0226600 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd02440 | CDD | 1 | 20.00 |