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IPR000683 is a Gfo/Idh/MocA-like oxidoreductase, N-terminal.
<p>This entry represents the N-terminal domain of a group of enzymes that utilise NADP or NAD, known as the GFO/IDH/MOCA family (GFO: glucose--fructose oxidoreductase, IDH: inositol 2-dehydrogenase and MOCA which catalyses a dehydrogenase reaction involved in rhizopine catabolism) in UniProtKB/Swiss-Prot, which includes enzymes that catalyse different chemical reactions such as oxidation and reduction of carbohydrates, oxidation of trans-dihydrodiols, reduction of biliverdin and hydrolysation of glycosidic bonds [[cite:PUB00094646]]. Other proteins belonging to this family include Gal80, a negative regulator for the expression of lactose and galactose metabolic genes, although it does not have enzymatic activity; and several hypothetical proteins from yeast, Escherichia coli and Bacillus subtilis.</p> <p>The Gfo/Idh/MocA protein family members have very low sequence identity but the 3D structures of the proteins are very similar, consisting of two main domains: an N-terminal dinucleotide-binding domain containing a typical Rossmann fold3 and a C-terminal α/β-domain participating in substrate binding and oligomerisation [[cite:PUB00094646]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Oxidoreductase-like protein [Solanum tuberosum] gi|413968618|gb|AFW90646.1| | 8 | ||
| – | Oxidoreductase family protein [Arabidopsis thaliana] gi|15233990|ref|NP_192705.1| | 9 | ||
| – | Oxidoreductase family protein [Arabidopsis lyrata subsp]. lyrata] gi|297813401|ref|XP_002874584.1| | 9 | ||
| – | Inositol 2-dehydrogenase [Medicago truncatula] gi|357476817|ref|XP_003608694.1| | 11 | ||
| – | NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana] gi|22331222|ref|NP_188715.2| | 11 | ||
| – | Oxidoreductase family protein; TAIR: AT4G09670.1 Oxidoreductase family protein; Swiss-Prot: sp|Q9SZ83|Y4967_ARATH Uncharacterized oxidoreductase At4g09670; TrEMBL-Plants: tr|I1JD96|I1JD96_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0099900 | 9 | ||
| – | Oxidoreductase family protein; TAIR: AT4G09670.1 Oxidoreductase family protein; Swiss-Prot: sp|Q9SZ83|Y4967_ARATH Uncharacterized oxidoreductase At4g09670; TrEMBL-Plants: tr|I1L3Q7|I1L3Q7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0168900 | 9 | ||
| – | Oxidoreductase, putative; TAIR: AT3G20790.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q04869|YM94_YEAST Uncharacterized protein YMR315W; TrEMBL-Plants: tr|I3T1A8|I3T1A8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0292900 | 11 | ||
| – | Oxidoreductase family, NAD-binding rossmann fold protein; TAIR: AT3G20790.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|Q04869|YM94_YEAST Uncharacterized protein YMR315W; TrEMBL-Plants: tr|I3T1A8|I3T1A8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0292900 | 11 | ||
| – | Inositol 2-dehydrogenase-like protein; TAIR: AT4G17370.1 Oxidoreductase family protein; Swiss-Prot: sp|O05389|YRBE_BACSU Uncharacterized oxidoreductase YrbE; TrEMBL-Plants: tr|I1K0R9|I1K0R9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0201600 | 9 | ||
| – | Inositol 2-dehydrogenase-like protein; TAIR: AT4G17370.1 Oxidoreductase family protein; Swiss-Prot: sp|O05389|YRBE_BACSU Uncharacterized oxidoreductase YrbE; TrEMBL-Plants: tr|I1K0R9|I1K0R9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0201600 | 10 | ||
| – | Inositol 2-dehydrogenase-like protein; TAIR: AT4G17370.1 Oxidoreductase family protein; Swiss-Prot: sp|O05389|YRBE_BACSU Uncharacterized oxidoreductase YrbE; TrEMBL-Plants: tr|I1K0R9|I1K0R9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0201600 | 10 | ||
| – | Oxidoreductase family protein; TAIR: AT4G09670.1 Oxidoreductase family protein; Swiss-Prot: sp|Q9SZ83|Y4967_ARATH Uncharacterized oxidoreductase At4g09670; TrEMBL-Plants: tr|G7J8P4|G7J8P4_MEDTR Oxidoreductase family, NAD-binding rossmann fold protein; Found in the gene: LotjaGi6g1v0053700 | 9 | ||
| – | Oxidoreductase family protein; TAIR: AT4G09670.1 Oxidoreductase family protein; Swiss-Prot: sp|Q9SZ83|Y4967_ARATH Uncharacterized oxidoreductase At4g09670; TrEMBL-Plants: tr|G7J8P4|G7J8P4_MEDTR Oxidoreductase family, NAD-binding rossmann fold protein; Found in the gene: LotjaGi6g1v0053700 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF55347 | SUPERFAMILY | 1 | 7.14 |