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IPR000933

Source: InterPro

Description

IPR000933 is a Glycoside hydrolase, family 29.

<p>O-Glycosyl hydrolases family 29 ([cazy:GH29]) encompasses alpha-L-fucosidases ([ec:3.2.1.51]) [[cite:PUB00000482]], which is a lysosomal enzyme responsible for hydrolysing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Alpha-L-fucosidase is responsible for hydrolysing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</p> <p>Fucosylated glycoconjugates are involved in numerous biological events, making alpha-l-fucosidases, the enzymes responsible for their processing, critically important. Deficiency in alpha-l-fucosidase activity is associated with fucosidosis, a lysosomal storage disorder characterised by rapid neurodegeneration, resulting in severe mental and motor deterioration [[cite:PUB00021761]]. The enzyme is a hexamer and displays a two-domain fold, composed of a catalytic (β/α)(8)-like domain and a C-terminal β-sandwich domain [[cite:PUB00021761]].</p> <p>Drosophila melanogaster spermatozoa contains an alpha-l-fucosidase that might be involved in fertilisation by interacting with alpha-l-fucose residues on the micropyle of the eggshell [[cite:PUB00043486]]. In human sperm, membrane-associated alpha-l-fucosidase is stable for extended periods of time, which is made possible by membrane domains and compartmentalisation. These help preserve protein integrity [[cite:PUB00043487]].</p> <p>O-Glycosyl hydrolases ([ec:3.2.1.]) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [[cite:PUB00004870], [cite:PUB00005266]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004560
Molecular function Alpha-L-fucosidase activity Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose.
Subterm of
GO:0005975
Biological process Carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
Subterm of

Associated Lotus transcripts 7

Transcript Name Description Predicted domains Domain count
Lj0g3v0241729.1
– PREDICTED: alpha-L-fucosidase 1-like [Cicer arietinum] gi|502119526|ref|XP_004496649.1|
Domains
17
Lj1g3v4657820.1
– PREDICTED: alpha-L-fucosidase 1-like [Cicer arietinum] gi|502119526|ref|XP_004496649.1|
Domains
17
Lj3g3v1113140.1
– PREDICTED: alpha-L-fucosidase 1-like [Cicer arietinum] gi|502082094|ref|XP_004487063.1|
Domains
17
Lj3g3v3056650.1
– PREDICTED: alpha-L-fucosidase 1-like [Cicer arietinum] gi|502082094|ref|XP_004487063.1|
Domains
17
LotjaGi3g1v0168000.1
– Alpha-L-fucosidase 1; TAIR: AT2G28100.1 alpha-L-fucosidase 1; Swiss-Prot: sp|Q8GW72|FUCO1_ARATH Alpha-L-fucosidase 1; TrEMBL-Plants: tr|A0A151QNQ9|A0A151QNQ9_CAJCA Alpha-L-fucosidase 1; Found in the gene: LotjaGi3g1v0168000
Domains
16
LotjaGi5g1v0307900.1
– Alpha-L-fucosidase 1; TAIR: AT2G28100.1 alpha-L-fucosidase 1; Swiss-Prot: sp|Q8GW72|FUCO1_ARATH Alpha-L-fucosidase 1; TrEMBL-Plants: tr|A0A1J7FTS4|A0A1J7FTS4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0307900
Domains
16
LotjaGi5g1v0307900.2
– Alpha-L-fucosidase 1; TAIR: AT2G28100.1 alpha-L-fucosidase 1; Swiss-Prot: sp|Q8GW72|FUCO1_ARATH Alpha-L-fucosidase 1; TrEMBL-Plants: tr|A0A1J7FTS4|A0A1J7FTS4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0307900
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SignalP-noTM SignalP_GRAM_NEGATIVE 1 14.29