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IPR001130 is a 3'-5' ssDNA/RNA exonuclease TatD-like.
<p>This protein family includes 3'-5' ssDNA/RNA exonuclease TatD and many uncharacterised deoxyribonucleases and metal-dependent hydrolases. The family is related to a large superfamily of metalloenzymes [[cite:PUB00004994]]. TatD has been shown to be a 3'-5' exonuclease that processes single-stranded DNA in DNA repair [[cite:PUB00007123], [cite:PUB00077112]].</p> <p>In E. coli TatD, which adopts a TIM-barrel fold, is encoded by a operon that encodes Tat proteins, including TatA, TatB, and TatC, for protein transport via the Tat (Twin-Arginine Translocation) pathway. However, TatD is not involved in the protein export in the Tat pathway [[cite:PUB00007123]].</p> <p>Deoxyribonuclease TATDN1 from Danio rerio (Zebrafish) catalyses (in vitro) the decatenation of kinetoplast DNA producing linear DNA molecules. It is involved in chromosomal segregation and cell cycle progression during eye development [[cite:PUB00100210]]. TATDN1 has been related to several types of cancer [[cite:PUB00100212], [cite:PUB00100209], [cite:PUB00100211]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Hydrolase activity, acting on ester bonds | Catalysis of the hydrolysis of any ester bond. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | TatD related DNase [Theobroma cacao] gi|508718401|gb|EOY10298.1| | 7 | ||
| – | TatD related DNase [Theobroma cacao] gi|508718401|gb|EOY10298.1| | 9 | ||
| – | TatD related DNase [Arabidopsis thaliana] gi|42572645|ref|NP_974418.1| | 7 | ||
| – | TatD related DNase [Arabidopsis thaliana] gi|79442300|ref|NP_190807.3| | 9 | ||
| – | TatD family; TAIR: AT3G52390.1 TatD related DNase; Swiss-Prot: sp|Q6P1N9|TATD1_HUMAN Putative deoxyribonuclease TATDN1; TrEMBL-Plants: tr|I3TAK4|I3TAK4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0737900 | 9 | ||
| – | TatD family; TAIR: AT3G52390.1 TatD related DNase; Swiss-Prot: sp|Q6P1N9|TATD1_HUMAN Putative deoxyribonuclease TATDN1; TrEMBL-Plants: tr|I3TAK4|I3TAK4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0737900 | 9 | ||
| – | TatD family; TAIR: AT3G52390.1 TatD related DNase; Swiss-Prot: sp|Q6P1N9|TATD1_HUMAN Putative deoxyribonuclease TATDN1; TrEMBL-Plants: tr|I3TAK4|I3TAK4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0737900 | 9 | ||
| – | TatD family; TAIR: AT5G17570.1 TatD related DNase; Swiss-Prot: sp|P37545|YABD_BACSU Uncharacterized metal-dependent hydrolase YabD; TrEMBL-Plants: tr|A0A072UIG3|A0A072UIG3_MEDTR TatD-related deoxyribonuclease; Found in the gene: LotjaGi2g1v0119500 | 8 | ||
| – | TatD family; TAIR: AT5G17570.1 TatD related DNase; Swiss-Prot: sp|P37545|YABD_BACSU Uncharacterized metal-dependent hydrolase YabD; TrEMBL-Plants: tr|A0A0S3T987|A0A0S3T987_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119500 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01310 | CDD | 1 | 11.11 |