Description

IPR001312 is a Hexokinase.

<p>Hexokinase ([ec:2.7.1.1]) [[cite:PUB00000566], [cite:PUB00001951]] is an important glycolytic enzyme that catalyses the phosphorylation of keto- and aldohexoses (e.g. glucose, mannose and fructose) using MgATP as the phosphoryl donor.</p> <p>In vertebrates there are four major isoenzymes, commonly referred as types I, II, III and IV. Type IV hexokinase, which is often incorrectly designated glucokinase [[cite:PUB00005375]], is only expressed in liver and pancreatic beta-cells and plays an important role in modulating insulin secretion; it is a protein of a molecular mass of about 50 Kd. Hexokinases of types I to III, which have low Km values for glucose, have a molecular mass of about 100 Kd. Structurally they consist of a very small N-terminal hydrophobic membrane-binding domain followed by two highly similar domains of 450 residues. The first domain has lost its catalytic activity and has evolved into a regulatory domain.</p> <p>In yeast there are three different isoenzymes: hexokinase PI (gene HXK1), PII (gene HXKB), and glucokinase (gene GLK1). All three proteins have a molecular mass of about 50 Kd.</p> <p>The hexokinase domain has an α/β fold and is distinctly folded in two subdomains of unequal size: the large and small subdomains. The large subdomain comprises a six-stranded mixed β-sheet and a number of additional α-helices. On one side, the sheet packs against the small subdomain, and on the other side it is shielded by several α-helices. The dominant feature of the small subdomain is a five stranded mixed β-sheet. The sheet is flanked by two helices on one side and by one helix on the other. The subdomain also has an additional β-sheet formed by two antiparallel strands [[cite:PUB00014215], [cite:PUB00036888]].</p> <p>All these enzymes contain one (or two in the case of types I to III isozymes) strongly conserved region which has been shown [[cite:PUB00000147]] to be involved in substrate binding.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: