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IPR001368 is a TNFR/NGFR cysteine-rich region.
<p>A number of proteins, some of which are known to be receptors for growth factors, have been found to contain a cysteine-rich domain of about 110 to 160 amino acids in their N-terminal part, that can be subdivided into four (or in some cases, three) modules of about 40 residues containing 6 conserved cysteines. Some of the proteins containing this domain are listed below [[cite:PUB00005358], [cite:PUB00001018], [cite:PUB00015257]]:</p> <ul> <li>Tumor Necrosis Factor type I and type II receptors (TNFR). Both receptors bind TNF-alpha and TNF-beta, but are only similar in the cysteine-rich region. TNFR contains four cysteine-rich domain modules (CRDs), termed CRD1 through CRD4. CRD2 and CRD3 are known as TNF-binding domains [[cite:PUB00000892]].</li> <li>Shope fibroma virus soluble TNF receptor (protein T2)</li> <li>Lymphotoxin alpha/beta receptor</li> <li>Low-affinity nerve growth factor receptor (LA-NGFR) (p75)</li> <li>CD40 (Bp50), the receptor for the CD40L (or TRAP) cytokine</li> <li>CD27, the receptor for the CD27L cytokine</li> <li>CD30, the receptor for the CD30L cytokine</li> <li>T-cell protein 4-1BB, the receptor for the 4-1BBL putative cytokine</li> <li>FAS antigen (or APO-1), the receptor for FASL, a protein involved in apoptosis (programmed cell death)</li> <li>T-cell antigen OX40, the receptor for the OX40L cytokine</li> <li>Wsl-1, a receptor (for a yet undefined ligand) that mediates apoptosis</li> <li>Vaccinia virus protein A53 (SalF19R)</li> </ul> <p>It has been shown [[cite:PUB00000892]] that the six cysteines all involved in intrachain disulphide bonds. A schematic representation of the structure of the 40 residue module of these receptors is shown below:</p> <pre> +-------------+ +--------------+ | | | | xCxxxxxxxxxxxxxCxCxxCxxxxxxxxxCxxxxCxx | | +------------+ 'C': conserved cysteine involved in a disulphide bond. </pre>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Serine/threonine protein kinase-like protein ACR4 [Medicago truncatula] gi|357454477|ref|XP_003597519.1| | 28 | ||
| – | PREDICTED: serine/threonine-protein kinase-like protein CCR1-like [Glycine max] gi|356536932|ref|XP_003536986.1| | 24 | ||
| – | Kinase family protein; TAIR: AT3G59420.1 crinkly4; Swiss-Prot: sp|Q9LX29|ACR4L_ARATH Serine/threonine-protein kinase-like protein ACR4; TrEMBL-Plants: tr|V7C0J8|V7C0J8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0033400 | 24 | ||
| – | Kinase family protein; TAIR: AT3G09780.1 CRINKLY4 related 1; Swiss-Prot: sp|Q9S7D9|ACCR1_ARATH Serine/threonine-protein kinase-like protein CCR1; TrEMBL-Plants: tr|V7BH39|V7BH39_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0077900 | 29 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |