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IPR001503 is a Glycosyl transferase family 10.
<p>The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates ([ec:2.4.1.-]) and related proteins into distinct sequence based families has been described [[cite:PUB00009409]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.</p> <p>Glycosyltransferase family 10 ([cazy:GT10]) comprises enzymes with two known activities; galactoside 3(4)-L-fucosyltransferase ([ec:2.4.1.65]) and galactoside 3-fucosyltransferase ([ec:2.4.1.152]).</p> <p>The galactoside 3-fucosyltransferases display similarities with the alpha-2 and alpha-6-fucosyltranferases [[cite:PUB00001989]]. The biosynthesis of the carbohydrate antigen sialyl Lewis X (sLe(x)) is dependent on the activity of an galactoside 3-fucosyltransferase. This enzyme catalyses the transfer of fucose from GDP-beta-fucose to the 3-OH of N-acetylglucosamine present in lactosamine acceptors [[cite:PUB00006364]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein glycosylation | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. | ||
| Molecular function | Fucosyltransferase activity | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. | ||
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Alpha 1,4-fucosyltransferase [Medicago truncatula] gi|45385175|gb|AAS59563.1| | 7 | ||
| – | PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A-like isoform X2 [Cicer arietinum] gi|502143113|ref|XP_004505222.1| | 10 | ||
| – | Alpha 1,3 fucosyltransferase; TAIR: AT1G49710.1 fucosyltransferase 12; Swiss-Prot: sp|Q9LJK1|FUT11_ARATH Glycoprotein 3-alpha-L-fucosyltransferase A; TrEMBL-Plants: tr|A0A0L9VAP5|A0A0L9VAP5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0074500 | 12 | ||
| – | Alpha-(1,4)-fucosyltransferase; TAIR: AT1G71990.1 fucosyltransferase 13; Swiss-Prot: sp|Q9C8W3|FUT13_ARATH Alpha-(1,4)-fucosyltransferase; TrEMBL-Plants: tr|A0A072VP38|A0A072VP38_MEDTR Alpha-(1,4)-fucosyltransferase-like protein; Found in the gene: LotjaGi5g1v0281100 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 25.00 |