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IPR001576 is a Phosphoglycerate kinase.
<p>Phosphoglycerate kinase ([ec:2.7.2.3]) (PGK) is an enzyme that catalyses the formation of ATP to ADP and vice versa. In the second step of the second phase in glycolysis, 1,3-diphosphoglycerate is converted to 3-phosphoglycerate, forming one molecule of ATP. If the reverse were to occur, one molecule of ADP would be formed. This reaction is essential in most cells for the generation of ATP in aerobes, for fermentation in anaerobes and for carbon fixation in plants.</p> <p>PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. The enzyme exists as a monomer containing two nearly equal-sized domains that correspond to the N-and C-termini of the protein (the last 15 C-terminal residues loop back into the N-terminal domain). 3-phosphoglycerate (3-PG) binds to the N-terminal, while the nucleotide substrates, MgATP or MgADP, bind to the C-terminal domain of the enzyme. This extended two-domain structure is associated with large-scale 'hinge-bending' conformational changes, similar to those found in hexokinase [[cite:PUB00006511]]. At the core of each domain is a 6-stranded parallel β-sheet surrounded by α helices. Domain 1 has a parallel β-sheet of six strands with an order of 342156, while domain 2 has a parallel β-sheet of six strands with an order of 321456. Analysis of the reversible unfolding of yeast phosphoglycerate kinase leads to the conclusion that the two lobes are capable of folding independently, consistent with the presence of intermediates on the folding pathway with a single domain folded [[cite:PUB00006255]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phosphoglycerate kinase activity | Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). | ||
| Biological process | Glycolytic process | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: phosphoglycerate kinase-like [Glycine max] gi|356551092|ref|XP_003543912.1| | 16 | ||
| – | Cytosolic phosphoglycerate kinase [Helianthus annuus] gi|121485004|gb|ABI18157.1| | 7 | ||
| – | Phosphoglycerate kinase [Medicago truncatula] gi|357451631|ref|XP_003596092.1| | 15 | ||
| – | Phosphoglycerate kinase [Medicago truncatula] gi|357451631|ref|XP_003596092.1| | 12 | ||
| – | PREDICTED: phosphoglycerate kinase, chloroplastic-like [Glycine max] gi|356525742|ref|XP_003531482.1| | 7 | ||
| – | PREDICTED: phosphoglycerate kinase, chloroplastic-like [Cicer arietinum] gi|502088191|ref|XP_004488763.1| | 21 | ||
| – | Phosphoglycerate kinase; TAIR: AT3G12780.1 phosphoglycerate kinase 1; Swiss-Prot: sp|Q31P73|PGK_SYNE7 Phosphoglycerate kinase; TrEMBL-Plants: tr|K7LXU3|K7LXU3_SOYBN Phosphoglycerate kinase; Found in the gene: LotjaGi2g1v0074400 | 15 | ||
| – | Phosphoglycerate kinase; TAIR: AT3G12780.1 phosphoglycerate kinase 1; Swiss-Prot: sp|Q31P73|PGK_SYNE7 Phosphoglycerate kinase; TrEMBL-Plants: tr|K7LXU3|K7LXU3_SOYBN Phosphoglycerate kinase; Found in the gene: LotjaGi2g1v0074400 | 15 | ||
| – | Phosphoglycerate kinase; TAIR: AT3G12780.1 phosphoglycerate kinase 1; Swiss-Prot: sp|Q31P73|PGK_SYNE7 Phosphoglycerate kinase; TrEMBL-Plants: tr|K7LXU9|K7LXU9_SOYBN Phosphoglycerate kinase; Found in the gene: LotjaGi2g1v0074400 | 15 | ||
| – | Phosphoglycerate kinase; TAIR: AT1G79550.1 phosphoglycerate kinase; Swiss-Prot: sp|Q42962|PGKY_TOBAC Phosphoglycerate kinase, cytosolic; TrEMBL-Plants: tr|G7IT86|G7IT86_MEDTR Phosphoglycerate kinase; Found in the gene: LotjaGi3g1v0134100 | 14 | ||
| – | Phosphoglycerate kinase; TAIR: AT1G79550.1 phosphoglycerate kinase; Swiss-Prot: sp|Q42962|PGKY_TOBAC Phosphoglycerate kinase, cytosolic; TrEMBL-Plants: tr|G7IT86|G7IT86_MEDTR Phosphoglycerate kinase; Found in the gene: LotjaGi3g1v0134100 | 14 | ||
| – | Phosphoglycerate kinase; TAIR: AT1G79550.1 phosphoglycerate kinase; Swiss-Prot: sp|Q42962|PGKY_TOBAC Phosphoglycerate kinase, cytosolic; TrEMBL-Plants: tr|G7IT86|G7IT86_MEDTR Phosphoglycerate kinase; Found in the gene: LotjaGi3g1v0134100 | 14 | ||
| – | Phosphoglycerate kinase; TAIR: AT1G56190.1 Phosphoglycerate kinase family protein; Swiss-Prot: sp|Q42961|PGKH_TOBAC Phosphoglycerate kinase, chloroplastic; TrEMBL-Plants: tr|G7IT85|G7IT85_MEDTR Phosphoglycerate kinase; Found in the gene: LotjaGi3g1v0134200 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00318 | CDD | 1 | 7.69 |