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IPR001630 is a cAMP response element binding (CREB) protein.
<p>Transcription initiation is dictated by the presence and activity of specific nuclear factors that bind to DNA regulatory sequences and interact with the transcriptional machinery. The functions of some of these factors can be altered by phosphorylation, which affects both DNA binding and transcriptional activation [[cite:PUB00000850]]. Phosphorylation is effected by specific protein kinases that have been activated by the stimulus of signal transduction pathways, resulting in the regulation of gene transcription by modulating the phosphorylation sites of transcription factors.</p> <p>Cyclic AMP (cAMP) regulates the expression of many genes via a conserved gene promoter element CRE (cAMP response element) [[cite:PUB00003661]], which has the sequence 5'-TGACGTCA-3' [[cite:PUB00004041]]. The cAMP response element binding protein (CREB) is a nuclear factor that is regulated by protein kinase A phosphorylation. Transcription is stimulated on binding to the CRE of a phosphorylated CREB dimer, which is held together by leucine zippers. Dimerisation and transcriptional efficacy have been found to be stimulated by phosphorylation at several distinct sites, and it has thus been suggested [[cite:PUB00003661]] that CREB may be regulated by multiple kinases. Sequence analysis of the gene has revealed a cluster of protein kinase A, protein kinase C, and casein kinase II consensus recognition sites near the N terminus of the protein sequence, and the proximity of these sites to one another indicates the possibility of interaction in a positive or negative fashion to regulate CREB bioactivity.</p> <p>The 'leucine zipper' is a structure that is believed to mediate the function of several eukaryotic gene regulatory proteins. The zipper consists of a periodic repetition of leucine residues at every seventh position, and regions containing them appear to span 8 turns of α-helix. The leucine side chains that extend from one helix interact with those from a similar helix, hence facilitating dimerisation in the form of a coiled-coil. Leucine zippers are present in many gene regulatory proteins, including the CREB proteins, Jun/AP1 transcription factors, fos oncogene and fos-related proteins, C-myc, L-myc and N-myc oncogenes, and so on.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Molecular function | DNA-binding transcription factor activity | A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. | ||
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | BZIP transcriptional repressor ROM1 [Phaseolus vulgaris] gi|1354857|gb|AAB36514.1| | 14 | ||
| – | BZIP transcription factor bZIP115 [Glycine max] gi|359806400|ref|NP_001240983.1| | 16 | ||
| – | Transcription factor; TAIR: AT4G36730.1 G-box binding factor 1; Swiss-Prot: sp|P42774|GBF1_ARATH G-box-binding factor 1; TrEMBL-Plants: tr|C6T9L6|C6T9L6_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0115400 | 16 | ||
| – | Transcription factor; TAIR: AT4G36730.1 G-box binding factor 1; Swiss-Prot: sp|P42774|GBF1_ARATH G-box-binding factor 1; TrEMBL-Plants: tr|C6T9L6|C6T9L6_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0115400 | 16 | ||
| – | Transcription factor; TAIR: AT4G36730.1 G-box binding factor 1; Swiss-Prot: sp|P42774|GBF1_ARATH G-box-binding factor 1; TrEMBL-Plants: tr|C6T9L6|C6T9L6_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0115400 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |