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IPR001734 is a Sodium/solute symporter.
<p>Sodium/substrate symport (or co-transport) is a widespread mechanism of solute transport across cytoplasmic membranes of pro-and eukaryotic cells. Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force, SMF) is used to drive solute accumulation against a concentration gradient. The SMF is generated by primary sodium pumps (e.g. sodium/potassium ATPases, sodium translocating respiratory chain complexes) or via the action of sodium/proton antiporters. Sodium/substrate transporters are grouped in different families based on sequence similarities [[cite:PUB00005080], [cite:PUB00000660]].</p> <p>One of these families, known as the sodium:solute symporter family (SSSF), contains over a hundred members of pro-and eukaryotic origin [[cite:PUB00009984]]. The average hydropathy plot for SSSF proteins predicts 11 to 15 putative transmembrane domains (TMs) in α-helical conformation. A secondary structure model of PutP from Escherichia coli suggests the protein contains 13 TMs with the N terminus located on the periplasmic side of the membrane and the C terminus facing the cytoplasm. The results support the idea of a common topological motif for members of the SSSF. Transporters with a C-terminal extension are proposed to have an additional 14th TM.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | ||
| Molecular function | Transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. | ||
| Biological process | Transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Urea active transporter-like protein [Medicago truncatula] gi|357484591|ref|XP_003612583.1| | 12 | ||
| – | Urea-proton symporter DUR3; TAIR: AT5G45380.1 urea-proton symporter DEGRADATION OF UREA 3 (DUR3); Swiss-Prot: sp|F4KD71|DUR3_ARATH Urea-proton symporter DUR3; TrEMBL-Plants: tr|G7K6S1|G7K6S1_MEDTR Sodium:solute symporter family protein; Found in the gene: LotjaGi2g1v0344400 | 13 | ||
| – | Urea-proton symporter DUR3; TAIR: AT5G45380.1 urea-proton symporter DEGRADATION OF UREA 3 (DUR3); Swiss-Prot: sp|F4KD71|DUR3_ARATH Urea-proton symporter DUR3; TrEMBL-Plants: tr|G7K6S1|G7K6S1_MEDTR Sodium:solute symporter family protein; Found in the gene: LotjaGi2g1v0344400 | 14 | ||
| – | Urea-proton symporter DUR3; TAIR: AT5G45380.1 urea-proton symporter DEGRADATION OF UREA 3 (DUR3); Swiss-Prot: sp|F4KD71|DUR3_ARATH Urea-proton symporter DUR3; TrEMBL-Plants: tr|A0A1J7HDL9|A0A1J7HDL9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0344400 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11476 | CDD | 1 | 25.00 |