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IPR001917 is a Aminotransferase, class-II, pyridoxal-phosphate binding site.
<p>Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped into subfamilies. One of these, is called class-II. It consists of Serine palmitoyltransferase ([ec:2.3.1.50]), Histidinol-phosphate aminotransferase ([ec:2.6.1.9]), Glycine acetyltransferase [ec:2.3.1.29]), 5-aminolevulinic acid synthase ([ec:2.3.1.37]) and 8-amino-7-oxononanoate synthase ([ec:2.3.1.47]).</p> <p>The crystal structures of a number of the aminotransferases have been determined including the structure of l-histidinol phosphate aminotransferase from Escherichia coli (HisC) [[cite:PUB00007901]]. HisC is a dimeric enzyme with a mass of approximately 80kDa. Like most pyridoxal-5'-phosphate (PLP)-dependent enzymes, each HisC monomer consists of two domains, a larger PLP-binding domain having an α/β/α topology, and a smaller domain. The N-terminal arm contributes to the dimerization of the two monomers. The PLP-binding domain of HisC shows weak sequence similarity, but significant structural similarity with the PLP-binding domains of a number of PLP-dependent enzymes.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 8-amino-7-oxononanoate synthase; TAIR: AT5G23670.1 long chain base2; Swiss-Prot: sp|Q2R3K3|LCB2A_ORYSJ Long chain base biosynthesis protein 2a; TrEMBL-Plants: tr|Q852R1|Q852R1_LOTJA Serine palmitoyltransferase; Found in the gene: LotjaGi4g1v0017900 | 17 | ||
| – | 8-amino-7-oxononanoate synthase; TAIR: AT5G23670.1 long chain base2; Swiss-Prot: sp|Q2R3K3|LCB2A_ORYSJ Long chain base biosynthesis protein 2a; TrEMBL-Plants: tr|Q852R1|Q852R1_LOTJA Serine palmitoyltransferase; Found in the gene: LotjaGi4g1v0017900 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06454 | CDD | 1 | 50.00 |