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IPR001917

Description

IPR001917 is a Aminotransferase, class-II, pyridoxal-phosphate binding site.

<p>Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped into subfamilies. One of these, is called class-II. It consists of Serine palmitoyltransferase ([ec:2.3.1.50]), Histidinol-phosphate aminotransferase ([ec:2.6.1.9]), Glycine acetyltransferase [ec:2.3.1.29]), 5-aminolevulinic acid synthase ([ec:2.3.1.37]) and 8-amino-7-oxononanoate synthase ([ec:2.3.1.47]).</p> <p>The crystal structures of a number of the aminotransferases have been determined including the structure of l-histidinol phosphate aminotransferase from Escherichia coli (HisC) [[cite:PUB00007901]]. HisC is a dimeric enzyme with a mass of approximately 80kDa. Like most pyridoxal-5'-phosphate (PLP)-dependent enzymes, each HisC monomer consists of two domains, a larger PLP-binding domain having an α/β/α topology, and a smaller domain. The N-terminal arm contributes to the dimerization of the two monomers. The PLP-binding domain of HisC shows weak sequence similarity, but significant structural similarity with the PLP-binding domains of a number of PLP-dependent enzymes.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
8-amino-7-oxononanoate synthase; TAIR: AT5G23670.1 long chain base2; Swiss-Prot: sp|Q2R3K3|LCB2A_ORYSJ Long chain base biosynthesis protein 2a; TrEMBL-Plants: tr|Q852R1|Q852R1_LOTJA Serine palmitoyltransferase; Found in the gene: LotjaGi4g1v0017900 17
8-amino-7-oxononanoate synthase; TAIR: AT5G23670.1 long chain base2; Swiss-Prot: sp|Q2R3K3|LCB2A_ORYSJ Long chain base biosynthesis protein 2a; TrEMBL-Plants: tr|Q852R1|Q852R1_LOTJA Serine palmitoyltransferase; Found in the gene: LotjaGi4g1v0017900 17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd06454 CDD 1 50.00