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IPR001998

Source: InterPro

Description

IPR001998 is a Xylose isomerase.

<p>Xylose isomerase ([ec:5.3.1.5]) [[cite:PUB00001569]] is an enzyme found in microorganisms which catalyzes the interconversion of D-xylose to D-xylulose. It can also isomerize D-ribose to D-ribulose and D-glucose to D-fructose. The enzyme is a homotetramer, which is stabilised by cobalt, and requires magnesium for its catalytic activity. Each subunit contains 2 domains: the core domain is a parallel α-β barrel; the C-terminal domain is a loop structure consisting of 5 helices and is involved in intermolecular contacts between adjacent subunits [[cite:PUB00003247]]. The active site lies in a deep pocket near the C-terminal ends of the strands of the barrel domain and includes residues from a second subunit. The tetramer is effectively a dimer of "active" dimers, the active sites being composed of residues from both subunits [[cite:PUB00003247]].</p> <p>Xylose isomerase also exists in plants [[cite:PUB00001465]] where it is homodimeric and is manganese-dependent.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005975
Biological process Carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.
Subterm of
GO:0009045
Molecular function Xylose isomerase activity Catalysis of the reaction: D-xylose = D-xylulose.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi4g1v0297300.1
– Xylose isomerase; TAIR: AT5G57655.2 xylose isomerase family protein; Swiss-Prot: sp|Q9FKK7|XYLA_ARATH Xylose isomerase; TrEMBL-Plants: tr|A0A0S3R851|A0A0S3R851_PHAAN Xylose isomerase; Found in the gene: LotjaGi4g1v0297300
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR02630 TIGRFAM 1 100.00