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IPR002466

Source: InterPro

Description

IPR002466 is a Adenosine deaminase/editase.

<p>Editase ([ec:3.5]) are enzymes that alter mRNA by catalyzing the site-selective deamination of adenosine residue into inosine residue. The editase domain contains the active site and binds three Zn atoms [[cite:PUB00006132]].</p> <p>Several editases share a common global arrangement of domains, from N to C terminus: two 'double-stranded RNA-specific adenosine deaminase' (DRADA) repeat domains, followed by three 'double-stranded RNA binding' (DsRBD) domains, followed by the editase domain. Other editases have a simplified domains structure with no DRADA_REP and possibly fewer DSRBD domains. Editase that deaminate cytidine are not detected by this signature.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003723
Molecular function RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Subterm of
GO:0004000
Molecular function Adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3.
Subterm of
GO:0006396
Biological process RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
Subterm of
Part of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj0g3v0318859.1
– PREDICTED: tRNA-specific adenosine deaminase 1-like isoform X1 [Cicer arietinum] gi|502157258|ref|XP_004510810.1|
Domains
4
Lj0g3v0318859.2
– PREDICTED: tRNA-specific adenosine deaminase 1-like isoform X1 [Cicer arietinum] gi|502157258|ref|XP_004510810.1|
Domains
5
Lj0g3v0318859.3
– PREDICTED: tRNA-specific adenosine deaminase 1-like isoform X1 [Cicer arietinum] gi|502157258|ref|XP_004510810.1|
Domains
5
LotjaGi3g1v0380800.1
– TRNA-specific adenosine deaminase 1; TAIR: AT1G01760.1 denosine deaminases acting on tRNA; Swiss-Prot: sp|Q9V3R6|ADAT1_DROME tRNA-specific adenosine deaminase 1; TrEMBL-Plants: tr|A0A151S3Q7|A0A151S3Q7_CAJCA tRNA-specific adenosine deaminase 1; Found in the gene: LotjaGi3g1v0380800
Domains
6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SM00552 SMART 1 25.00