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IPR002470 is a Peptidase S9A, prolyl oligopeptidase.
<p>This group of serine peptidases belong to MEROPS peptidase family S9 (clan SC), subfamily S9A (prolyl oligopeptidase) which includes PREP and PREPL from human [[cite:PUB00151503]], fungal prolyl oligopeptidases such as ophP, ledP, dbiP which are part of the gene cluster that mediates the biosynthesis of omphalotin A, lentinulin A, and dendrothelin A, respectively, methylated cyclic dodecapeptides with nematodicidal activity [[cite:PUB00105757], [cite:PUB00151504]].</p> <p>Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [[cite:PUB00003576]]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence [[cite:PUB00003576]]. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [[cite:PUB00003576]].</p> <p>Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base [[cite:PUB00003576]]. The geometric orientations of the catalytic residues are similar between families, despite different protein folds [[cite:PUB00003576]]. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [[cite:PUB00003576], [cite:PUB00000522]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). | ||
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: prolyl endopeptidase-like [Glycine max] gi|356508957|ref|XP_003523219.1| | 15 | ||
| – | Prolyl endopeptidase-like protein [Medicago truncatula] gi|357488089|ref|XP_003614332.1| | 10 | ||
| – | Prolyl endopeptidase-like protein [Medicago truncatula] gi|357488089|ref|XP_003614332.1| | 12 | ||
| – | Prolyl endopeptidase-like protein [Medicago truncatula] gi|357488089|ref|XP_003614332.1| | 8 | ||
| – | PREDICTED: protease 2-like [Cicer arietinum] gi|502094624|ref|XP_004490262.1| | 8 | ||
| – | PREDICTED: protease 2-like [Glycine max] gi|356502217|ref|XP_003519916.1| | 9 | ||
| – | PREDICTED: protease 2-like [Glycine max] gi|356502217|ref|XP_003519916.1| | 9 | ||
| – | PREDICTED: protease 2-like [Glycine max] gi|356502217|ref|XP_003519916.1| | 9 | ||
| – | PREDICTED: protease 2-like [Cicer arietinum] gi|502153025|ref|XP_004509189.1| | 9 | ||
| – | PREDICTED: prolyl endopeptidase-like [Glycine max] gi|356553325|ref|XP_003545007.1| | 15 | ||
| – | PREDICTED: protease 2-like [Glycine max] gi|356575387|ref|XP_003555823.1| | 21 | ||
| – | Prolyl endopeptidase; TAIR: AT1G76140.1 Prolyl oligopeptidase family protein; Swiss-Prot: sp|P48147|PPCE_HUMAN Prolyl endopeptidase; TrEMBL-Plants: tr|I1JSY1|I1JSY1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0433700 | 15 | ||
| – | Prolyl endopeptidase; TAIR: AT1G76140.1 Prolyl oligopeptidase family protein; Swiss-Prot: sp|Q9QUR6|PPCE_MOUSE Prolyl endopeptidase; TrEMBL-Plants: tr|I1JSY1|I1JSY1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0433700 | 16 | ||
| – | Prolyl endopeptidase; TAIR: AT1G76140.1 Prolyl oligopeptidase family protein; Swiss-Prot: sp|Q9QUR6|PPCE_MOUSE Prolyl endopeptidase; TrEMBL-Plants: tr|I1JSY1|I1JSY1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0433700 | 16 | ||
| – | Protease 2; TAIR: AT5G66960.1 Prolyl oligopeptidase family protein; Swiss-Prot: sp|O07834|DAPB1_PSEMX Dipeptidyl aminopeptidase BI; TrEMBL-Plants: tr|A0A0R0FXW8|A0A0R0FXW8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0110900 | 15 | ||
| – | Prolyl endopeptidase; TAIR: AT1G76140.1 Prolyl oligopeptidase family protein; Swiss-Prot: sp|P48147|PPCE_HUMAN Prolyl endopeptidase; TrEMBL-Plants: tr|A0A0R0GGG0|A0A0R0GGG0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0002400 | 15 | ||
| – | Prolyl endopeptidase; TAIR: AT1G76140.1 Prolyl oligopeptidase family protein; Swiss-Prot: sp|P48147|PPCE_HUMAN Prolyl endopeptidase; TrEMBL-Plants: tr|A0A0R0GGG0|A0A0R0GGG0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0002400 | 15 | ||
| – | Prolyl oligopeptidase family protein; TAIR: AT1G50380.2 Prolyl oligopeptidase family protein; Swiss-Prot: sp|O07834|DAPB1_PSEMX Dipeptidyl aminopeptidase BI; TrEMBL-Plants: tr|I1NF29|I1NF29_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0355000 | 20 | ||
| – | Prolyl oligopeptidase family protein; TAIR: AT1G50380.2 Prolyl oligopeptidase family protein; Swiss-Prot: sp|O07834|DAPB1_PSEMX Dipeptidyl aminopeptidase BI; TrEMBL-Plants: tr|I1NF29|I1NF29_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0355000 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF53474 | SUPERFAMILY | 1 | 5.26 |