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IPR002480

Source: InterPro

Description

IPR002480 is a DAHP synthetase, class II.

<p>Members of the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase family ([ec:2.5.1.54]) catalyse the first step in aromatic amino acid biosynthesis from chorismate. Class I (see [interpro:IPR006218]) includes bacterial and yeast enzymes; class II includes higher plants and various microorganisms [[cite:PUB00006352]]. They have minimal sequence identity and different regulatory and oligomeric properties, however, they have structural similarities that indicate a common ancestry for the class I and class II DAHPSs [[cite:PUB00039551]].</p> <p>The first step in the common pathway leading to the biosynthesis of aromatic compounds is the stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) [[cite:PUB00039551]]. This reaction is catalyzed by DAHP synthase, a metal-activated enzyme, which in microorganisms is the target for negative-feedback regulation by pathway intermediates or by end products.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003849
Molecular function 3-deoxy-7-phosphoheptulonate synthase activity Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate.
Subterm of
GO:0009073
Biological process Aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
Subterm of

Associated Lotus transcripts 12

Transcript Name Description Predicted domains Domain count
Lj0g3v0105319.1
– PREDICTED: phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic-like [Fragaria vesca subsp]. vesca] gi|470127404|ref|XP_004299659.1|
Domains
7
Lj1g3v0261660.1
– PREDICTED: phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic-like [Glycine max] gi|356500707|ref|XP_003519173.1|
Domains
5
Lj1g3v0261750.1
– 3-deoxy-7-phosphoheptulonate synthase [Lactuca sativa] gi|73912412|dbj|BAE20405.1|
Domains
5
Lj1g3v0261770.1
– 2-dehydro-3-deoxyphosphoheptonate aldolase (3-deoxy-d-arabino-heptulosonate 7-phosphate synthase) [Medicago truncatula] gi|357489731|ref|XP_003615153.1|
Domains
5
Lj1g3v0263110.1
– PREDICTED: phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic-like [Cicer arietinum] gi|502177864|ref|XP_004516132.1|
Domains
7
Lj1g3v0263120.1
–
Domains
10
Lj6g3v2204800.1
– PREDICTED: phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic-like [Glycine max] gi|356554708|ref|XP_003545685.1|
Domains
11
Lj6g3v2204810.1
– PREDICTED: phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic-like [Glycine max] gi|356554708|ref|XP_003545685.1|
Domains
5
LotjaGi1g1v0143000.1
– Phospho-2-dehydro-3-deoxyheptonate aldolase; TAIR: AT1G22410.1 Class-II DAHP synthetase family protein; Swiss-Prot: sp|P27608|AROF_TOBAC Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic; TrEMBL-Plants: tr|I1JGU8|I1JGU8_SOYBN Phospho-2-dehydro-3-deoxyheptonate aldolase; Found in the gene: LotjaGi1g1v0143000
Domains
9
LotjaGi1g1v0143000.2
– Phospho-2-dehydro-3-deoxyheptonate aldolase; TAIR: AT1G22410.1 Class-II DAHP synthetase family protein; Swiss-Prot: sp|P27608|AROF_TOBAC Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic; TrEMBL-Plants: tr|I1JGU8|I1JGU8_SOYBN Phospho-2-dehydro-3-deoxyheptonate aldolase; Found in the gene: LotjaGi1g1v0143000
Domains
9
LotjaGi1g1v0239000.1
– Phospho-2-dehydro-3-deoxyheptonate aldolase; TAIR: AT1G22410.1 Class-II DAHP synthetase family protein; Swiss-Prot: sp|P27608|AROF_TOBAC Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic; TrEMBL-Plants: tr|A0A1J7HUV8|A0A1J7HUV8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0239000
Domains
9
LotjaGi6g1v0351200.1
– Phospho-2-dehydro-3-deoxyheptonate aldolase; TAIR: AT4G33510.1 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase; Swiss-Prot: sp|Q00218|AROG_ARATH Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic; TrEMBL-Plants: tr|A0A151T7J8|A0A151T7J8_CAJCA Phospho-2-dehydro-3-deoxyheptonate aldolase; Found in the gene: LotjaGi6g1v0351200
Domains
13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR01358 TIGRFAM 1 8.33