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IPR002821

Source: InterPro

Description

IPR002821 is a Hydantoinase A/oxoprolinase.

<p>This domain is found in the enzymes hydantoinase A (HyuA) and oxoprolinase ([ec:3.5.2.9]). Both enzymes catalyse reactions involving the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [[cite:PUB00005769]]. This domain is also found in (4-{4-[2-(gamma-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase from <i>Methanocaldococcus jannaschii</i>, which is involved in methanofuran biosynthesis, catalysing the condensation between 5-(aminomethyl)-3-furanmethanol diphosphate and gamma-glutamyltyramine to produce 4-[N-(gamma-L-glutamyl)-p-(beta-aminoethyl)phenoxymethyl]-(aminomethyl)furan (APMF-Glu) [[cite:PUB00077118]]. D-5-(2-methylthioethyl)hydantoin amidohydrolase (HyuA) from<i>Pseudomonas</i> is a component of the hydantoinase process, an enzymatic cascade converting D-5-(2-methylthioethyl)hydantoin to N-carbamoyl-D-methionine [[cite:PUB00019732]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016787
Molecular function Hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj4g3v0365720.1
– PREDICTED: 5-oxoprolinase-like [Glycine max] gi|356524810|ref|XP_003531021.1|
Domains
9
LotjaGi4g1v0038800.1
– 5-oxoprolinase; TAIR: AT5G37830.1 oxoprolinase 1; Swiss-Prot: sp|Q9FIZ7|OPLA_ARATH 5-oxoprolinase; TrEMBL-Plants: tr|I1KQZ7|I1KQZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0038800
Domains
9
LotjaGi4g1v0038800.2
– 5-oxoprolinase; TAIR: AT5G37830.1 oxoprolinase 1; Swiss-Prot: sp|Q9FIZ7|OPLA_ARATH 5-oxoprolinase; TrEMBL-Plants: tr|I1KQZ7|I1KQZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0038800
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
PTHR11365:SF2 PANTHER 1 33.33