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IPR003692 is a Hydantoinase B/oxoprolinase.
An appreciable fraction of the sulphur present in mammals occurs in the form of glutathione. The synthesis of glutathione and its utilization take place by the reactions of the gamma-glutamyl cycle, which include those catalysed by gamma-glutamylcysteine and glutathione synthetases, gamma-glutamyl transpeptidase, cysteinylglycinase, gamma-glutamyl cyclotransferease, and 5-oxoprolinase [[PMID:45011]]. This domain is found in N-methylhydantoinase B, which converts hydantoin to N-carbamyl-amino acids, and in 5-oxoprolinase [ec:3.5.2.9] which catalyses the formation of L-glutamate from 5-oxo-L-proline. These enzymes are part of the oxoprolinase family.
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 5-oxoprolinase-like [Glycine max] gi|356524810|ref|XP_003531021.1| | 9 | ||
| – | 5-oxoprolinase; TAIR: AT5G37830.1 oxoprolinase 1; Swiss-Prot: sp|Q9FIZ7|OPLA_ARATH 5-oxoprolinase; TrEMBL-Plants: tr|I1KQZ7|I1KQZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0038800 | 9 | ||
| – | 5-oxoprolinase; TAIR: AT5G37830.1 oxoprolinase 1; Swiss-Prot: sp|Q9FIZ7|OPLA_ARATH 5-oxoprolinase; TrEMBL-Plants: tr|I1KQZ7|I1KQZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0038800 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR11365:SF2 | PANTHER | 1 | 33.33 |