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IPR002836

Source: InterPro

Description

IPR002836 is a PDCD5-like.

<p>This protein family is found in archaea and eukaryota. Proteins in this family contain a predicted DNA-binding domain [[cite:PUB00008047]] and may function as DNA-binding proteins. Methanobacterium thermoautotrophicum MTH1615 was predicted to bind DNA based on structural proteomics data, and this was confirmed by the demonstration that it can interact non-specifically with a randomly chosen 20-mer of double stranded DNA [[cite:PUB00008047]]. This suggests that the human protein may be involved in nucleic acid binding or metabolism.</p> <p>The human programmed cell death protein 5 (PDCD5, also known as TFAR19) encodes a protein which shares significant homology to the corresponding proteins of species ranging from yeast to mice. PDCD5 exhibits a ubiquitous expression pattern and its expression is up-regulated in the tumour cells undergoing apoptosis. PDCD5 may play a general role in the apoptotic process [[cite:PUB00006429], [cite:PUB00048246]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003677
Molecular function DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj4g3v0282320.1
– PREDICTED: DNA-binding protein DDB_G0278111-like isoform X2 [Cicer arietinum] gi|502141936|ref|XP_004504711.1|
Domains
8
LotjaGi4g1v0025700.1
– DNA-binding; TAIR: AT1G29850.1 double-stranded DNA-binding family protein; Swiss-Prot: sp|O14737|PDCD5_HUMAN Programmed cell death protein 5; TrEMBL-Plants: tr|I3S3B2|I3S3B2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0025700
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00