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IPR002853

Source: InterPro

Description

IPR002853 is a Transcription initiation factor IIE subunit alpha, N-terminal.

<p>This entry represents the conserved N-terminal region of eukaryotic TFIIE-alpha and proteins from archaebacteria (TFE) that are also presumed to be TFIIE-alpha subunits [[cite:PUB00005802]].</p> <p>Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit ([interpro:IPR002853]) and the small beta ([interpro:IPR003166]). TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [[cite:PUB00006521]].</p> <p>The TFIIE β-central core DNA-binding domain consists of three helices with a β-hairpin at the C terminus, resembling the winged helix proteins. It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [[cite:PUB00006521]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006367
Biological process Transcription initiation from RNA polymerase II promoter Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
Subterm of
Part of

Associated Lotus transcripts 14

Transcript Name Description Predicted domains Domain count
Lj0g3v0198759.2
– PREDICTED: general transcription factor IIE subunit 1-like [Glycine max] gi|356563109|ref|XP_003549808.1|
Domains
14
Lj0g3v0198759.3
– PREDICTED: general transcription factor IIE subunit 1-like [Cicer arietinum] gi|502151714|ref|XP_004508577.1|
Domains
15
Lj4g3v0599890.1
– PREDICTED: general transcription factor IIE subunit 1-like [Cicer arietinum] gi|502151714|ref|XP_004508577.1|
Domains
15
LotjaGi1g1v0346400.1
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|Q557M8|T2EA_DICDI General transcription factor IIE subunit 1; TrEMBL-Plants: tr|A0A0S3R7K1|A0A0S3R7K1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0346400
Domains
13
LotjaGi2g1v0144100_LC.1
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1K1A1|I1K1A1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0144100_LC
Domains
15
LotjaGi2g1v0144100_LC.11
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1K1A1|I1K1A1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0144100_LC
Domains
15
LotjaGi2g1v0144100_LC.2
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1K1A1|I1K1A1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0144100_LC
Domains
14
LotjaGi2g1v0144100_LC.5
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1K1A1|I1K1A1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0144100_LC
Domains
14
LotjaGi2g1v0144100_LC.6
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1K1A1|I1K1A1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0144100_LC
Domains
14
LotjaGi2g1v0144100_LC.8
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1K1A1|I1K1A1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0144100_LC
Domains
14
LotjaGi2g1v0144100_LC.9
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1K1A1|I1K1A1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0144100_LC
Domains
14
LotjaGi4g1v0074700.1
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|A0A0S3R7K1|A0A0S3R7K1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0074700
Domains
15
LotjaGi4g1v0074700.2
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1MUG7|I1MUG7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0074700
Domains
15
LotjaGi4g1v0074700.3
– Transcription initiation factor IIE subunit alpha; TAIR: AT1G03280.1 Transcription factor TFIIE, alpha subunit; Swiss-Prot: sp|P36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha; TrEMBL-Plants: tr|I1MUG7|I1MUG7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0074700
Domains
15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 7.14