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IPR003021

Source: InterPro

Description

IPR003021 is a Rad1/Rec1/Rad17.

<p>This family consists of the repair proteins Rad1, Rec1 and Rad17.</p> <p>Rad1 is a component of the 9-1-1 cell-cycle checkpoint response complex (Rad9-Rad1-Hus1) that plays a major role in DNA repair [[cite:PUB00059226], [cite:PUB00059227]]. Rad1 isoform 1 possesses 3'->5' double stranded DNA exonuclease activity [[cite:PUB00062235]].</p> <p>Rec1 of Ustilago maydis plays a key role in regulating the genetic system of this fungus. Rec1 mutants are very sensitive to UV light. Mutation leads to a complex phenotype with alterations in DNA repair, recombination, mutagenesis, meiosis and cell division [[cite:PUB00006116]]. Rec1 shows 3'--5' exonuclease activity, but only in cells over-expressing Rec1.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000077
Biological process DNA damage checkpoint A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
Subterm of
GO:0042025
Cellular component Host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0290399.1
– PREDICTED: cell cycle checkpoint protein RAD1-like [Cucumis sativus] gi|449462759|ref|XP_004149108.1|
Domains
6
LotjaGi3g1v0298200.1
– Cell cycle checkpoint protein RAD1; TAIR: AT4G17760.1 PCNA domain-containing protein; Swiss-Prot: sp|Q9QWZ1|RAD1_MOUSE Cell cycle checkpoint protein RAD1; TrEMBL-Plants: tr|V7CHL1|V7CHL1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0298200
Domains
6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00577 CDD 1 50.00