Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR003115 is a ParB/Sulfiredoxin.
<p>This entry represents a domain, known as ParB/Srx domain, that is involved in nucleotide binding. Proteins containing this domain include Escherichia coli plasmid protein ParB and mammalian Sulfiredoxin-1 (Srx). A conserved GxxRxxA motif forms the ATP-binding pocket in Srx [[cite:PUB00153776]]. Mutations in the corresponding ParB residues lead to loss of function and sub-cellular localisation defects in Bacillus subtilis [[cite:PUB00153775]]. This pocket in ParB binds ribonucleotide cytidine triphosphate (CTP). CTP binding is necessary to stabilise the domain in a conformation that facilitates its interaction with ParA [[cite:PUB00153758]]. CTP binding modulates the parS-binding affinity of ParB, whereas specific recognition of a parS motif stimulates CTP hydrolysis.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: sulfiredoxin, chloroplastic/mitochondrial-like [Fragaria vesca subsp]. vesca] gi|470115153|ref|XP_004293767.1| | 8 | ||
| – | Sulfiredoxin; TAIR: AT1G31170.1 sulfiredoxin; Swiss-Prot: sp|Q8GY89|SRX_ARATH Sulfiredoxin, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I3T533|I3T533_LOTJA Sulfiredoxin; Found in the gene: LotjaGi4g1v0083000 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |