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IPR003333 is a Cyclopropane mycolic acid synthase.
<p>This entry represents cyclopropane mycolic acid synthases (CMAS) and related enzymes, including CmaA1, CmaA2 (cyclopropane mycolic acid synthase A1 and A2), MmaA1-4 (methoxymycolic acid synthase A1-4) and tuberculostearic acid methyltransferase UfaA1. All are thought to be S-adenosyl-L-methionine (SAM) utilising methyltransferases [[cite:PUB00022044]]. This entry also includes S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis, which is a methyltransferase that modifies short-chain fatty acids [[cite:PUB00077550]].</p> <p>Mycolic acid cyclopropane synthase or cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase) [ec:2.1.1.79] catalyses the reaction:</p> <reaction> S-adenosyl-L-methionine + phospholipid olefinic fatty acid ->S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.</reaction> <p>The major mycolic acid produced by Mycobacterium tuberculosis contains two cis-cyclopropanes in the meromycolate chain. Cyclopropanation may contribute to the structural integrity of the cell wall complex [[cite:PUB00008119]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Lipid biosynthetic process | The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: (S)-coclaurine N-methyltransferase-like isoform X2 [Cicer arietinum] gi|502132614|ref|XP_004501447.1| | 9 | ||
| – | Methyltransferase, putative; TAIR: AT4G33110.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q5C9L6|CNMT_THLFG (S)-coclaurine N-methyltransferase; TrEMBL-Plants: tr|A0A067KCV9|A0A067KCV9_JATCU Uncharacterized protein; Found in the gene: LotjaGi1g1v0369000 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02440 | CDD | 1 | 50.00 |