Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR003386 is a Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase.
<p>This entry represents a group of lipid metabolizing enzymes, including LACT and LPLA2 from humans, and PDAT from plants.</p> <p>Lecithin:cholesterol acyltransferase (LACT), also known as phosphatidylcholine-sterol acyltransferase ([ec:2.3.1.43]), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Its structure has been revealed [[cite:PUB00093993]]. Defects in LACT cause Fish eye disease and familial LCAT deficiency [[cite:PUB00093994]].</p> <p>Phospholipid:diacylglycerol acyltransferase (PDAT)([ec:2.3.1.158]) is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid [[cite:PUB00055421]].</p> <p>Lysosomal phospholipase A2 (LPLA2) ([ec:3.1.1.5]) plays important roles for lung surfactant metabolism and maturation of invariant natural killer T cells. Its structure has been revealed [[cite:PUB00093995]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. | ||
| Molecular function | O-acyltransferase activity | Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phospholipase A1 [Medicago truncatula] gi|357507845|ref|XP_003624211.1| | 7 | ||
| – | PREDICTED: phospholipid--sterol O-acyltransferase-like [Glycine max] gi|356570658|ref|XP_003553502.1| | 15 | ||
| – | PREDICTED: phospholipid:diacylglycerol acyltransferase 1-like [Cicer arietinum] gi|502156358|ref|XP_004510434.1| | 12 | ||
| – | Group XV phospholipase A2 [Medicago truncatula] gi|357475183|ref|XP_003607877.1| | 7 | ||
| – | PREDICTED: phospholipid:diacylglycerol acyltransferase 1-like [Glycine max] gi|356545746|ref|XP_003541296.1| | 12 | ||
| – | Lecithin-cholesterol acyltransferase-like 1; TAIR: AT1G27480.1 alpha/beta-Hydrolases superfamily protein; Swiss-Prot: sp|Q9FZI8|LCAT1_ARATH Lecithin-cholesterol acyltransferase-like 1; TrEMBL-Plants: tr|I3S9F8|I3S9F8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0362500 | 13 | ||
| – | Lecithin:cholesterol acyltransferase family protein; TAIR: AT3G03310.1 lecithin:cholesterol acyltransferase 3; Swiss-Prot: sp|Q93V61|LCAT3_ARATH Phospholipase A(1) LCAT3; TrEMBL-Plants: tr|G7KSE0|G7KSE0_MEDTR Lecithin:cholesterol acyltransferase family protein; Found in the gene: LotjaGi1g1v0487700 | 6 | ||
| – | Phospholipid--sterol O-acyltransferase; TAIR: AT1G04010.1 phospholipid sterol acyl transferase 1; Swiss-Prot: sp|Q4VCM1|LCAT2_ARATH Phospholipid--sterol O-acyltransferase; TrEMBL-Plants: tr|K7MYQ9|K7MYQ9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0706200 | 14 | ||
| – | Phospholipid--sterol O-acyltransferase; TAIR: AT1G04010.1 phospholipid sterol acyl transferase 1; Swiss-Prot: sp|Q4VCM1|LCAT2_ARATH Phospholipid--sterol O-acyltransferase; TrEMBL-Plants: tr|I1N9T0|I1N9T0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0706200 | 14 | ||
| – | Phospholipid--sterol O-acyltransferase; TAIR: AT1G04010.1 phospholipid sterol acyl transferase 1; Swiss-Prot: sp|Q4VCM1|LCAT2_ARATH Phospholipid--sterol O-acyltransferase; TrEMBL-Plants: tr|K7MYQ9|K7MYQ9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0706200 | 14 | ||
| – | Phospholipid--sterol O-acyltransferase; TAIR: AT1G04010.1 phospholipid sterol acyl transferase 1; Swiss-Prot: sp|Q4VCM1|LCAT2_ARATH Phospholipid--sterol O-acyltransferase; TrEMBL-Plants: tr|K7MYQ9|K7MYQ9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0706200 | 14 | ||
| – | Phospholipid:diacylglycerol acyltransferase; TAIR: AT1G04010.1 phospholipid sterol acyl transferase 1; Swiss-Prot: sp|Q4VCM1|LCAT2_ARATH Phospholipid--sterol O-acyltransferase; TrEMBL-Plants: tr|I1N9T0|I1N9T0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0706200 | 14 | ||
| – | Phospholipid--sterol O-acyltransferase; TAIR: AT1G04010.1 phospholipid sterol acyl transferase 1; Swiss-Prot: sp|Q4VCM1|LCAT2_ARATH Phospholipid--sterol O-acyltransferase; TrEMBL-Plants: tr|I1N9T0|I1N9T0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0706200 | 4 | ||
| – | Phospholipid:diacylglycerol acyltransferase; TAIR: AT5G13640.1 phospholipid:diacylglycerol acyltransferase; Swiss-Prot: sp|Q9FNA9|PDAT1_ARATH Phospholipid:diacylglycerol acyltransferase 1; TrEMBL-Plants: tr|A0A1J7HW47|A0A1J7HW47_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0417200 | 12 | ||
| – | Phospholipid:diacylglycerol acyltransferase; TAIR: AT3G44830.1 Lecithin:cholesterol acyltransferase family protein; Swiss-Prot: sp|Q9FYC7|PDAT2_ARATH Putative phospholipid:diacylglycerol acyltransferase 2; TrEMBL-Plants: tr|A0A0B2QHW1|A0A0B2QHW1_GLYSO Putative phospholipid:diacylglycerol acyltransferase 2; Found in the gene: LotjaGi3g1v0481600 | 11 | ||
| – | Phospholipid:diacylglycerol acyltransferase; TAIR: AT3G44830.1 Lecithin:cholesterol acyltransferase family protein; Swiss-Prot: sp|Q9FYC7|PDAT2_ARATH Putative phospholipid:diacylglycerol acyltransferase 2; TrEMBL-Plants: tr|A0A072UKK7|A0A072UKK7_MEDTR Phosphatidylcholine-sterol acyltransferase; Found in the gene: LotjaGi3g1v0481600 | 11 | ||
| – | Lecithin:cholesterol acyltransferase; TAIR: AT4G19860.1 alpha/beta-Hydrolases superfamily protein; Swiss-Prot: sp|Q71N54|LCAT4_ARATH Lecithin-cholesterol acyltransferase-like 4; TrEMBL-Plants: tr|A2Q294|A2Q294_MEDTR Lecithin:cholesterol acyltransferase; Found in the gene: LotjaGi4g1v0084600 | 6 | ||
| – | Phospholipid:diacylglycerol acyltransferase; TAIR: AT5G13640.1 phospholipid:diacylglycerol acyltransferase; Swiss-Prot: sp|Q9FNA9|PDAT1_ARATH Phospholipid:diacylglycerol acyltransferase 1; TrEMBL-Plants: tr|I1LY35|I1LY35_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0327500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 5.56 |