Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR003437 is a Glycine dehydrogenase (decarboxylating).
<p>The P protein, also known as Glycine dehydrogenase (decarboxylating), is part of the glycine decarboxylase multienzyme complex (GDC), also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T [[cite:PUB00009491]]. The P protein ([ec:1.4.4.2]) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor, carbon dioxide is released and the remaining methylamin moiety is then transferred to the lipoamide cofactor of the H protein. The reaction catalysed by this protein is:</p> <p><reaction>Glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2</reaction></p> <p>The subunit composition of glycine cleavage system P proteins have been classified into two types. Those from eukaryotes and some of the P proteins from prokaryotes (e.g. Escherichia coli) are in the homodimeric form. The rest of those from prokaryotes are heterotetrameric, with two different subunits which, based on sequence similarities, correspond respectively to the N and C-terminal halves of the eukaryotic subunit [[cite:PUB00038183]].</p> <p>This entry represents the P protein homodimeric subfamily, which is found in eukaryotes and some prokaryotes, such as E. coli.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glycine dehydrogenase (decarboxylating) activity | Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. | ||
| Biological process | Glycine metabolic process | The chemical reactions and pathways involving glycine, aminoethanoic acid. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glycine dehydrogenase [decarboxylating] gi|502125338|ref|XP_004498895.1| | 12 | ||
| – | Glycine dehydrogenase decarboxylating protein; TAIR: AT2G26080.1 glycine decarboxylase P-protein 2; Swiss-Prot: sp|P26969|GCSP_PEA Glycine dehydrogenase (decarboxylating), mitochondrial; TrEMBL-Plants: tr|I1M923|I1M923_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0044000 | 14 | ||
| – | Glycine dehydrogenase decarboxylating protein; TAIR: AT2G26080.1 glycine decarboxylase P-protein 2; Swiss-Prot: sp|P26969|GCSP_PEA Glycine dehydrogenase (decarboxylating), mitochondrial; TrEMBL-Plants: tr|I1M923|I1M923_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0044000 | 14 | ||
| – | Glycine dehydrogenase decarboxylating protein; TAIR: AT2G26080.1 glycine decarboxylase P-protein 2; Swiss-Prot: sp|P26969|GCSP_PEA Glycine dehydrogenase (decarboxylating), mitochondrial; TrEMBL-Plants: tr|I1M923|I1M923_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0044000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |