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IPR003697

Source: InterPro

Description

IPR003697 is a Nucleoside triphosphate pyrophosphatase Maf-like protein.

<p>The Maf protein of Bacillus subtilis shares substantial amino acid sequence identity with Escherichia coli YhdE (previously known as OrfE) [[cite:PUB00008179]]. Maf-like proteins are conserved in bacteria, archaea, and eukaryotes. Maf proteins have been implicated in cell division arrest [[cite:PUB00083351]]. It has also been proposed that they belong to a family of house-cleaning nucleotide hydrolyzing enzymes which prevent the incorporation of noncanonical nucleotides into cellular DNA [[cite:PUB00079689]]. Maf proteins exhibit nucleotide pyrophosphatase activity against canonical and modified nucleotides, which might represent a molecular mechanism for this dual role in cell division arrest and in house-cleaning [[cite:PUB00083350]].</p> <p>This entry includes pyrophosphatases, such as YhdE and YceF from E. coli. YhdE is a nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP [[cite:PUB00083350], [cite:PUB00092592], [cite:PUB00092593]]. YceF is a nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m7GTP) [[cite:PUB00092594]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0047429
Molecular function Nucleoside-triphosphate diphosphatase activity Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide.
Subterm of

Associated Lotus transcripts 10

Transcript Name Description Predicted domains Domain count
Lj4g3v0961070.1
– PREDICTED: maf-like protein DDB_G0281937-like [Glycine max] gi|356561237|ref|XP_003548889.1|
Domains
9
Lj5g3v0104850.1
– PREDICTED: maf-like protein DDB_G0281937-like isoform X2 [Cicer arietinum] gi|502126048|ref|XP_004499160.1|
Domains
5
Lj5g3v0104850.2
– PREDICTED: maf-like protein DDB_G0281937-like isoform 2 [Fragaria vesca subsp]. vesca] gi|470111278|ref|XP_004291875.1|
Domains
5
Lj5g3v0106040.1
– Maf-like protein [Arachis hypogaea] gi|194466227|gb|ACF74344.1|
Domains
5
LotjaGi1g1v0416900.1
– Maf-like protein; TAIR: AT5G66550.1 Maf-like protein; Swiss-Prot: sp|Q54TC5|MAFL2_DICDI Maf-like protein DDB_G0281937; TrEMBL-Plants: tr|I1MNF8|I1MNF8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0416900
Domains
10
LotjaGi4g1v0117500.1
– Maf-like protein; TAIR: AT5G66550.2 Maf-like protein; Swiss-Prot: sp|Q54TC5|MAFL2_DICDI Maf-like protein DDB_G0281937; TrEMBL-Plants: tr|I1MNF8|I1MNF8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0117500
Domains
16
LotjaGi5g1v0015700.1
– Maf-like protein; TAIR: AT5G42770.3 Maf-like protein; Swiss-Prot: sp|Q54TC5|MAFL2_DICDI Maf-like protein DDB_G0281937; TrEMBL-Plants: tr|I3T5C3|I3T5C3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0015700
Domains
10
LotjaGi5g1v0015700.2
– Maf-like protein; TAIR: AT5G42770.3 Maf-like protein; Swiss-Prot: sp|Q54TC5|MAFL2_DICDI Maf-like protein DDB_G0281937; TrEMBL-Plants: tr|I3T5C3|I3T5C3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0015700
Domains
9
LotjaGi5g1v0015700.3
– Maf-like protein; TAIR: AT5G42770.3 Maf-like protein; Swiss-Prot: sp|Q54TC5|MAFL2_DICDI Maf-like protein DDB_G0281937; TrEMBL-Plants: tr|K7MNV4|K7MNV4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0015700
Domains
10
LotjaGi5g1v0015700.4
– Maf-like protein; TAIR: AT5G42770.2 Maf-like protein; Swiss-Prot: sp|Q54TC5|MAFL2_DICDI Maf-like protein DDB_G0281937; TrEMBL-Plants: tr|A0A0S3RQ97|A0A0S3RQ97_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0015700
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00555 CDD 1 10.00