Description

IPR004131 is a Pyrophosphate-energised proton pump.

<p>Two types of proteins that hydrolyse inorganic pyrophosphate (PPi), very different in both amino acid sequence and structure, have been characterised to date: soluble and membrane-bound proton-pumping pyrophosphatases (sPPases and H+)-PPases, respectively). sPPases are ubiquitous proteins that hydrolyse PPi to release heat, whereas H+-PPases, so far unidentified in animal and fungal cells, couple the energy of PPi hydrolysis to proton movement across biological membranes [[cite:PUB00014387]]. The latter type is represented by this group of proteins. H+-PPases ([ec:3.6.1.1]) are also called vacuolar-type inorganic pyrophosphatases (V-PPase) or pyrophosphate-energised vacuolar membrane proton pumps [[cite:PUB00014458]]. In plants, vacuoles contain two enzymes for acidifying the interior of the vacuole, the V-ATPase and the V-PPase (V is for vacuolar) [[cite:PUB00014387]]. In Arabidopsis, AVP1 contributes to H+-electrochemical potential difference between the citosol and vacuole lumen and also facilitates auxin transport by modulating apoplastic pH and regulates auxin-mediated developmental processes [[cite:PUB00097876]].</p> <p>Two distinct biochemical subclasses of H+-PPases have been characterised to date: K+-stimulated and K+-insensitive [[cite:PUB00014458]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: