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IPR004528 is a 3-deoxy-D-manno-octulosonate cytidylyltransferase.
<p>3-Deoxy-D-manno-octulosonate cytidylyltransferase ([ec:2.7.7.38]) activates KDO, a required 8-carbon sugar, for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. It acts as a homodimer and catalyses the conversion of CTP and 3-deoxy-D-manno-octulosonate into CMP-3-deoxy-D-manno-octulosonate and pyrophosphate [[cite:PUB00080738], [cite:PUB00025543]]. KDO is an essential component of the lipopolysaccharide found in the outer surface of Gram-negative eubacteria. It is also a constituent of the capsular polysaccharides of some Gram-negative eubacteria. Its presence in the cell wall polysaccharides of green algae and plant were also discovered. However, they have not been found in yeast and animals. The absence of the enzyme in mammalian cells makes it an attractive target molecule for drug design [[cite:PUB00080739]].</p> <p>This family also includes 8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase ([ec:2.7.7.90]). This enzyme activates KDO8N, the 8-aminated form of KDO, for incorporation into bacterial lipopolysaccharide in the Shewanella genus. KDO8N is found exclusively in marine bacteria of the genus Shewanella [[cite:PUB00082311]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | 3-deoxy-manno-octulosonate cytidylyltransferase activity | Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 3-deoxy-manno-octulosonate cytidylyltransferase-like [Glycine max] gi|356543296|ref|XP_003540098.1| | 9 | ||
| – | PREDICTED: 3-deoxy-manno-octulosonate cytidylyltransferase-like [Glycine max] gi|356543296|ref|XP_003540098.1| | 15 | ||
| – | Nucleotide-diphospho-sugar transferases superfamily protein isoform 1 [Theobroma cacao] gi|508721052|gb|EOY12949.1| | 15 | ||
| – | 3-deoxy-manno-octulosonate cytidylyltransferase; TAIR: AT1G53000.1 Nucleotide-diphospho-sugar transferases superfamily protein; Swiss-Prot: sp|Q9C920|KDSB_ARATH 3-deoxy-manno-octulosonate cytidylyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A072VK14|A0A072VK14_MEDTR 3-deoxy-manno-octulosonate cytidylyltransferase; Found in the gene: LotjaGi3g1v0047800_LC | 14 | ||
| – | 3-deoxy-manno-octulosonate cytidylyltransferase; TAIR: AT1G53000.1 Nucleotide-diphospho-sugar transferases superfamily protein; Swiss-Prot: sp|Q9C920|KDSB_ARATH 3-deoxy-manno-octulosonate cytidylyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A072VK14|A0A072VK14_MEDTR 3-deoxy-manno-octulosonate cytidylyltransferase; Found in the gene: LotjaGi3g1v0047800_LC | 14 | ||
| – | 3-deoxy-manno-octulosonate cytidylyltransferase; TAIR: AT1G53000.1 Nucleotide-diphospho-sugar transferases superfamily protein; Swiss-Prot: sp|Q9C920|KDSB_ARATH 3-deoxy-manno-octulosonate cytidylyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A072VK14|A0A072VK14_MEDTR 3-deoxy-manno-octulosonate cytidylyltransferase; Found in the gene: LotjaGi3g1v0047900 | 15 | ||
| – | 3-deoxy-manno-octulosonate cytidylyltransferase; TAIR: AT1G53000.1 Nucleotide-diphospho-sugar transferases superfamily protein; Swiss-Prot: sp|Q9C920|KDSB_ARATH 3-deoxy-manno-octulosonate cytidylyltransferase, mitochondrial; TrEMBL-Plants: tr|A0A072VK14|A0A072VK14_MEDTR 3-deoxy-manno-octulosonate cytidylyltransferase; Found in the gene: LotjaGi3g1v0181300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02517 | CDD | 1 | 14.29 |