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IPR004854 is a Ubiquitin fusion degradation protein Ufd1-like.
<p>This entry includes Ubiquitin fusion degradation protein Ufd1 from fungi and Ufd1-like proteins from animals and plants.</p> <p>Ufd1 is part of the Ufd1-Npl4 complex that functions as the substrate-recruiting cofactor for Cdc48 segregase. The Cdc48-Ufd1-Npl4 complex is involved in degradation of misfolded ER proteins [[cite:PUB00085171]]. The Ufd1-Npl4 complex has been found to recruit Cdc48 to ubiquitylated CMG (Cdc45-MCM-GINS) helicase at the end of chromosome replication, thereby driving the disassembly reaction [[cite:PUB00085175]].</p> <p>In humans, Npl4-Ufd1 acts as a cofactor in reducing antiviral innate immune responses by facilitating proteasomal degradation of RIG-I (a viral RNA sensor) [[cite:PUB00085176]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | CM0545.430.nc [Lotus japonicus] gi|164605542|dbj|BAF98608.1| | 3 | ||
| – | CM0545.430.nc [Lotus japonicus] gi|164605542|dbj|BAF98608.1| | 6 | ||
| – | Ubiquitin fusion degradation protein-like protein [Medicago truncatula] gi|357472787|ref|XP_003606678.1| | 5 | ||
| – | Ubiquitin fusion degradation protein-like protein [Medicago truncatula] gi|357472787|ref|XP_003606678.1| | 5 | ||
| – | Ubiquitin fusion degradation protein [Medicago truncatula] gi|357521303|ref|XP_003630940.1| | 5 | ||
| – | PREDICTED: ubiquitin fusion degradation protein 1 homolog [Cicer arietinum] gi|502148487|ref|XP_004507181.1| | 5 | ||
| – | Ubiquitin fusion degradation protein 1 like; TAIR: AT4G15420.2 Ubiquitin fusion degradation UFD1 family protein; Swiss-Prot: sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|B0BLB9|B0BLB9_LOTJA CM0545.430.nc protein; Found in the gene: LotjaGi1g1v0062200 | 9 | ||
| – | Ubiquitin fusion degradation protein 1 like; TAIR: AT4G15420.2 Ubiquitin fusion degradation UFD1 family protein; Swiss-Prot: sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|B0BLB9|B0BLB9_LOTJA CM0545.430.nc protein; Found in the gene: LotjaGi1g1v0062200 | 7 | ||
| – | Ubiquitin fusion degradation protein 1 like; TAIR: AT2G29070.1 Ubiquitin fusion degradation UFD1 family protein; Swiss-Prot: sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|A0A1J7H776|A0A1J7H776_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0375600 | 8 | ||
| – | Ubiquitin fusion degradation 1 protein; TAIR: AT2G21270.1 ubiquitin fusion degradation 1; Swiss-Prot: sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|G7LAK8|G7LAK8_MEDTR Ubiquitin fusion degradation 1 protein; Found in the gene: LotjaGi4g1v0456800 | 8 | ||
| – | Ubiquitin fusion degradation 1 protein; TAIR: AT2G21270.1 ubiquitin fusion degradation 1; Swiss-Prot: sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|G7LAK8|G7LAK8_MEDTR Ubiquitin fusion degradation 1 protein; Found in the gene: LotjaGi4g1v0456800 | 8 | ||
| – | Ubiquitin fusion degradation 1 protein; TAIR: AT2G21270.1 ubiquitin fusion degradation 1; Swiss-Prot: sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|G7LAK8|G7LAK8_MEDTR Ubiquitin fusion degradation 1 protein; Found in the gene: LotjaGi4g1v0456800 | 8 | ||
| – | Ubiquitin fusion degradation 1 protein; TAIR: AT2G21270.1 ubiquitin fusion degradation 1; Swiss-Prot: sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|G7LAK8|G7LAK8_MEDTR Ubiquitin fusion degradation 1 protein; Found in the gene: LotjaGi4g1v0456800 | 8 | ||
| – | Ubiquitin fusion degradation 1 protein; TAIR: AT2G21270.1 ubiquitin fusion degradation 1; Swiss-Prot: sp|P70362|UFD1_MOUSE Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|G7LAK8|G7LAK8_MEDTR Ubiquitin fusion degradation 1 protein; Found in the gene: LotjaGi4g1v0456800 | 8 | ||
| – | Ubiquitin fusion degradation 1 protein; TAIR: AT2G29070.2 Ubiquitin fusion degradation UFD1 family protein; Swiss-Prot: sp|Q92890|UFD1_HUMAN Ubiquitin fusion degradation protein 1 homolog; TrEMBL-Plants: tr|A0A1J7H776|A0A1J7H776_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0227500 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 6.67 |