Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR005339 is a GINS complex, subunit Psf1.
<p>DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the prereplication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.</p> <p>Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [[cite:PUB00012381], [cite:PUB00015004]]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases [[cite:PUB00015004]]. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [[cite:PUB00012381], [cite:PUB00015004]]. Electron microscopy of GINS shows that it forms a ring-like structure [[cite:PUB00012381]], reminiscent of the structure of PCNA [[cite:PUB00015005]], the DNA polymerase delta replication clamp.This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [[cite:PUB00012381]].</p> <p>This family of proteins represents the PSF1 component (for partner of SLD five) of the GINS complex.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | GINS complex | A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. | ||
| Biological process | DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable DNA replication complex GINS protein PSF1-like [Cicer arietinum] gi|502124772|ref|XP_004498667.1| | 7 | ||
| – | DNA replication complex GINS protein PSF1 [Medicago truncatula] gi|357455431|ref|XP_003597996.1| | 4 | ||
| – | DNA replication complex GINS protein PSF1; TAIR: AT1G80190.1 partner of SLD five 1; Swiss-Prot: sp|Q14691|PSF1_HUMAN DNA replication complex GINS protein PSF1; TrEMBL-Plants: tr|I3SFL3|I3SFL3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0107600 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11710 | CDD | 1 | 33.33 |