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IPR005595

Source: InterPro

Description

IPR005595 is a Translocon-associated protein (TRAP), alpha subunit.

<p>The alpha-subunit of the TRAP (translocon-associated protein, also known as signal sequence receptor 1/alpha subunit, SSRA) complex is a single-spanning membrane protein of the endoplasmic reticulum (ER) [[cite:PUB00008468], [cite:PUB00101524]]. The four-subunit (alpha, beta, gamma and delta) TRAP complex localises in the ER membrane and associates with the Sec61 translocon as a heterotetramer [[cite:PUB00070948]]. It also interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins [[cite:PUB00070949]]. TRAP complex may also be involved in endoplasmic reticulum-associated degradation [[cite:PUB00070947]]. TRAP-alpha plays a critical role in the biosynthesis of insulin, being involved in preproinsulin translocation and proinsulin trafficking which may contribute to the pathogenesis of type 2 diabetes [[cite:PUB00101524]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005789
Cellular component Endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Subterm of
Part of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj3g3v3530630.1
– PREDICTED: translocon-associated protein subunit alpha-like [Cicer arietinum] gi|502144432|ref|XP_004505694.1|
Domains
8
LotjaGi3g1v0531800.1
– Translocon-associated protein subunit alpha; TAIR: AT2G16595.1 Translocon-associated protein (TRAP), alpha subunit; Swiss-Prot: sp|P45434|SSRA_ARATH Translocon-associated protein subunit alpha; TrEMBL-Plants: tr|I3SEK1|I3SEK1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0531800
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 50.00