Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR005654 is a ATPase, AFG1-like.
<p>This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE.</p> <p>ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family [[cite:PUB00019112]].</p> <p>AFG1-like ATPase (also known as lactation elevated 1 or LACE1), the mammalian homologue of AGF1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain [[cite:PUB00081939]].</p> <p>ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks the future site of the septum of bacterial cell division [[cite:PUB00074167], [cite:PUB00105925]. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions suggesting that ZapE is a stress-regulated cell division protein [[cite:PUB00105926]]. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro [[cite:PUB00074167]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: lactation elevated protein 1-like [Glycine max] gi|356564878|ref|XP_003550674.1| | 4 | ||
| – | PREDICTED: lactation elevated protein 1-like [Glycine max] gi|356564878|ref|XP_003550674.1| | 8 | ||
| – | PREDICTED: lactation elevated protein 1-like isoform X1 [Cicer arietinum] gi|502124766|ref|XP_004498664.1| | 8 | ||
| – | Lactation elevated protein 1; TAIR: AT4G30490.1 AFG1-like ATPase family protein; Swiss-Prot: sp|Q3V384|LACE1_MOUSE Lactation elevated protein 1; TrEMBL-Plants: tr|K7MKA9|K7MKA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0292300 | 8 | ||
| – | Lactation elevated protein 1; TAIR: AT4G30490.1 AFG1-like ATPase family protein; Swiss-Prot: sp|Q3V384|LACE1_MOUSE Lactation elevated protein 1; TrEMBL-Plants: tr|K7MKA9|K7MKA9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0292300 | 8 | ||
| – | Lactation elevated protein 1; TAIR: AT2G25530.1 AFG1-like ATPase family protein; Swiss-Prot: sp|Q32PX9|LACE1_RAT Lactation elevated protein 1; TrEMBL-Plants: tr|K7MN10|K7MN10_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0060900 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF52540 | SUPERFAMILY | 1 | 16.67 |